Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application
The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5- endo-dig cyclization pathway as their forma...
Gespeichert in:
| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2018, Vol.47 (37), p.12838-12842 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12842 |
|---|---|
| container_issue | 37 |
| container_start_page | 12838 |
| container_title | Dalton transactions : an international journal of inorganic chemistry |
| container_volume | 47 |
| creator | Chung, Lai-Hon Ng, Sze-Wing Yeung, Chi-Fung Shek, Hau-Lam Tse, Sheung-Ying Lo, Hoi-Shing Chan, Siu-Chung Tse, Man-Kit Yiu, Shek-Man Wong, Chun-Yuen |
| description | The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-
endo-dig
cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.
The first examples of metal-indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines. |
| doi_str_mv | 10.1039/c8dt02408a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_30004548</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070237083</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-ddab598cb1762a472a2c6b80a616936f329655bfcf77d1fc92bef3c4c3f345013</originalsourceid><addsrcrecordid>eNpdkk1v1DAQhiNERUvhwh1kiQtCDfgjiRNu1bYUpEpIqJwjZzJhXRw7tZ3tbn8vPwTvblkkJEtjzTwz7yuPs-wVox8YFc1HqPtIeUFr9SQ7YYWUecNF8fRw59Vx9jyEW0o5pyV_lh0LSmlRFvVJ9vv7HJdo9Tzm2vbO6AdtnUUCbpwMrjEQlQ6xeE_AqBCIG8iIURkVsSdLjOgdbMBo2LW42fbhE9E26J_LmGJ0ZLbg7Apt1M4qQ5T5tUkCCqJeqW2OTCou79UmnBGPKzT7ZNKZLa4nhK0QmhS9s0lm8m5CH_XWmk2V9WScP_SM2GvQO51pSq52hRfZ0aBMwJeP8TT78fnyZvElv_529XVxfp2DEDLmfa-6sqmhY7LiqpBccai6mqqKVY2oBsGbqiy7AQYpezZAwzscBBQgBlGUlInT7N1-bvJ4N2OI7agDoDHKoptDy6mkXEhai4S-_Q-9dbNPvhPFGJMsiRWJer-nwLsQPA7t5PWo_KZltN3uvl3UFze73Z8n-M3jyLlLz3BA_y47Aa_3gA9wqP77POIPTQO7dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2111713294</pqid></control><display><type>article</type><title>Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Chung, Lai-Hon ; Ng, Sze-Wing ; Yeung, Chi-Fung ; Shek, Hau-Lam ; Tse, Sheung-Ying ; Lo, Hoi-Shing ; Chan, Siu-Chung ; Tse, Man-Kit ; Yiu, Shek-Man ; Wong, Chun-Yuen</creator><creatorcontrib>Chung, Lai-Hon ; Ng, Sze-Wing ; Yeung, Chi-Fung ; Shek, Hau-Lam ; Tse, Sheung-Ying ; Lo, Hoi-Shing ; Chan, Siu-Chung ; Tse, Man-Kit ; Yiu, Shek-Man ; Wong, Chun-Yuen</creatorcontrib><description>The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-
endo-dig
cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.
The first examples of metal-indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/c8dt02408a</identifier><identifier>PMID: 30004548</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Alkynes ; Crystallography ; Heterocyclic compounds ; NMR ; Nuclear magnetic resonance ; Ruthenium ; Toxicity</subject><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2018, Vol.47 (37), p.12838-12842</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-ddab598cb1762a472a2c6b80a616936f329655bfcf77d1fc92bef3c4c3f345013</citedby><cites>FETCH-LOGICAL-c337t-ddab598cb1762a472a2c6b80a616936f329655bfcf77d1fc92bef3c4c3f345013</cites><orcidid>0000-0001-5728-9624 ; 0000-0002-7882-0848 ; 0000-0002-9613-0218 ; 0000-0002-0482-1362 ; 0000-0002-6536-2489 ; 0000-0002-2011-7391 ; 0000-0003-4449-341X ; 0000-0003-1444-6989 ; 0000-0003-0907-5634 ; 0000-0003-4780-480X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30004548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Lai-Hon</creatorcontrib><creatorcontrib>Ng, Sze-Wing</creatorcontrib><creatorcontrib>Yeung, Chi-Fung</creatorcontrib><creatorcontrib>Shek, Hau-Lam</creatorcontrib><creatorcontrib>Tse, Sheung-Ying</creatorcontrib><creatorcontrib>Lo, Hoi-Shing</creatorcontrib><creatorcontrib>Chan, Siu-Chung</creatorcontrib><creatorcontrib>Tse, Man-Kit</creatorcontrib><creatorcontrib>Yiu, Shek-Man</creatorcontrib><creatorcontrib>Wong, Chun-Yuen</creatorcontrib><title>Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application</title><title>Dalton transactions : an international journal of inorganic chemistry</title><addtitle>Dalton Trans</addtitle><description>The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-
endo-dig
cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.
The first examples of metal-indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines.</description><subject>Alkynes</subject><subject>Crystallography</subject><subject>Heterocyclic compounds</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ruthenium</subject><subject>Toxicity</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkk1v1DAQhiNERUvhwh1kiQtCDfgjiRNu1bYUpEpIqJwjZzJhXRw7tZ3tbn8vPwTvblkkJEtjzTwz7yuPs-wVox8YFc1HqPtIeUFr9SQ7YYWUecNF8fRw59Vx9jyEW0o5pyV_lh0LSmlRFvVJ9vv7HJdo9Tzm2vbO6AdtnUUCbpwMrjEQlQ6xeE_AqBCIG8iIURkVsSdLjOgdbMBo2LW42fbhE9E26J_LmGJ0ZLbg7Apt1M4qQ5T5tUkCCqJeqW2OTCou79UmnBGPKzT7ZNKZLa4nhK0QmhS9s0lm8m5CH_XWmk2V9WScP_SM2GvQO51pSq52hRfZ0aBMwJeP8TT78fnyZvElv_529XVxfp2DEDLmfa-6sqmhY7LiqpBccai6mqqKVY2oBsGbqiy7AQYpezZAwzscBBQgBlGUlInT7N1-bvJ4N2OI7agDoDHKoptDy6mkXEhai4S-_Q-9dbNPvhPFGJMsiRWJer-nwLsQPA7t5PWo_KZltN3uvl3UFze73Z8n-M3jyLlLz3BA_y47Aa_3gA9wqP77POIPTQO7dg</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Chung, Lai-Hon</creator><creator>Ng, Sze-Wing</creator><creator>Yeung, Chi-Fung</creator><creator>Shek, Hau-Lam</creator><creator>Tse, Sheung-Ying</creator><creator>Lo, Hoi-Shing</creator><creator>Chan, Siu-Chung</creator><creator>Tse, Man-Kit</creator><creator>Yiu, Shek-Man</creator><creator>Wong, Chun-Yuen</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5728-9624</orcidid><orcidid>https://orcid.org/0000-0002-7882-0848</orcidid><orcidid>https://orcid.org/0000-0002-9613-0218</orcidid><orcidid>https://orcid.org/0000-0002-0482-1362</orcidid><orcidid>https://orcid.org/0000-0002-6536-2489</orcidid><orcidid>https://orcid.org/0000-0002-2011-7391</orcidid><orcidid>https://orcid.org/0000-0003-4449-341X</orcidid><orcidid>https://orcid.org/0000-0003-1444-6989</orcidid><orcidid>https://orcid.org/0000-0003-0907-5634</orcidid><orcidid>https://orcid.org/0000-0003-4780-480X</orcidid></search><sort><creationdate>2018</creationdate><title>Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application</title><author>Chung, Lai-Hon ; Ng, Sze-Wing ; Yeung, Chi-Fung ; Shek, Hau-Lam ; Tse, Sheung-Ying ; Lo, Hoi-Shing ; Chan, Siu-Chung ; Tse, Man-Kit ; Yiu, Shek-Man ; Wong, Chun-Yuen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-ddab598cb1762a472a2c6b80a616936f329655bfcf77d1fc92bef3c4c3f345013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alkynes</topic><topic>Crystallography</topic><topic>Heterocyclic compounds</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Ruthenium</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Lai-Hon</creatorcontrib><creatorcontrib>Ng, Sze-Wing</creatorcontrib><creatorcontrib>Yeung, Chi-Fung</creatorcontrib><creatorcontrib>Shek, Hau-Lam</creatorcontrib><creatorcontrib>Tse, Sheung-Ying</creatorcontrib><creatorcontrib>Lo, Hoi-Shing</creatorcontrib><creatorcontrib>Chan, Siu-Chung</creatorcontrib><creatorcontrib>Tse, Man-Kit</creatorcontrib><creatorcontrib>Yiu, Shek-Man</creatorcontrib><creatorcontrib>Wong, Chun-Yuen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Lai-Hon</au><au>Ng, Sze-Wing</au><au>Yeung, Chi-Fung</au><au>Shek, Hau-Lam</au><au>Tse, Sheung-Ying</au><au>Lo, Hoi-Shing</au><au>Chan, Siu-Chung</au><au>Tse, Man-Kit</au><au>Yiu, Shek-Man</au><au>Wong, Chun-Yuen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><addtitle>Dalton Trans</addtitle><date>2018</date><risdate>2018</risdate><volume>47</volume><issue>37</issue><spage>12838</spage><epage>12842</epage><pages>12838-12842</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-
endo-dig
cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.
The first examples of metal-indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30004548</pmid><doi>10.1039/c8dt02408a</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-5728-9624</orcidid><orcidid>https://orcid.org/0000-0002-7882-0848</orcidid><orcidid>https://orcid.org/0000-0002-9613-0218</orcidid><orcidid>https://orcid.org/0000-0002-0482-1362</orcidid><orcidid>https://orcid.org/0000-0002-6536-2489</orcidid><orcidid>https://orcid.org/0000-0002-2011-7391</orcidid><orcidid>https://orcid.org/0000-0003-4449-341X</orcidid><orcidid>https://orcid.org/0000-0003-1444-6989</orcidid><orcidid>https://orcid.org/0000-0003-0907-5634</orcidid><orcidid>https://orcid.org/0000-0003-4780-480X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2018, Vol.47 (37), p.12838-12842 |
| issn | 1477-9226 1477-9234 |
| language | eng |
| recordid | cdi_pubmed_primary_30004548 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkynes Crystallography Heterocyclic compounds NMR Nuclear magnetic resonance Ruthenium Toxicity |
| title | Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T19%3A24%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ruthenium-indolizinone%20complexes%20as%20a%20new%20class%20of%20metalated%20heterocyclic%20compounds:%20insight%20into%20unconventional%20alkyne%20activation%20pathways,%20revelation%20of%20unexpected%20electronic%20properties%20and%20exploration%20of%20medicinal%20application&rft.jtitle=Dalton%20transactions%20:%20an%20international%20journal%20of%20inorganic%20chemistry&rft.au=Chung,%20Lai-Hon&rft.date=2018&rft.volume=47&rft.issue=37&rft.spage=12838&rft.epage=12842&rft.pages=12838-12842&rft.issn=1477-9226&rft.eissn=1477-9234&rft_id=info:doi/10.1039/c8dt02408a&rft_dat=%3Cproquest_pubme%3E2070237083%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2111713294&rft_id=info:pmid/30004548&rfr_iscdi=true |