Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine
The density of platelet alpha 2-adrenoceptors, quantitated by means of the binding of [3H]clonidine and [3H]yohimbine, and the aggregation response induced by adrenaline were investigated in thirty-two heroin addicts during spontaneous withdrawal. The number of binding sites for [3H]clonidine, but n...
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| Veröffentlicht in: | European journal of pharmacology 1985-08, Vol.114 (3), p.365 |
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| creator | Garcia-Sevilla, J A Ugedo, L Ulibarri, I Gutierrez, M |
| description | The density of platelet alpha 2-adrenoceptors, quantitated by means of the binding of [3H]clonidine and [3H]yohimbine, and the aggregation response induced by adrenaline were investigated in thirty-two heroin addicts during spontaneous withdrawal. The number of binding sites for [3H]clonidine, but not for [3H]yohimbine, was significantly increased during withdrawal and the increase followed a time course related to the severity of the abstinence syndrome. There was a positive and significant correlation between the severity of withdrawal and the density of platelet alpha 2-adrenoceptors. Concomitantly, the adrenaline-induced platelet aggregation was potentiated. Treatment with clonidine led to significant decreases in receptor densities as well as in functional responses. These results suggest that only alpha 2-adrenoceptors in the agonist state (i.e. number of binding sites for [3H]clonidine) are modulated during the development of the heroin withdrawal syndrome. |
| doi_str_mv | 10.1016/0014-2999(85)90382-6 |
| format | Article |
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The number of binding sites for [3H]clonidine, but not for [3H]yohimbine, was significantly increased during withdrawal and the increase followed a time course related to the severity of the abstinence syndrome. There was a positive and significant correlation between the severity of withdrawal and the density of platelet alpha 2-adrenoceptors. Concomitantly, the adrenaline-induced platelet aggregation was potentiated. Treatment with clonidine led to significant decreases in receptor densities as well as in functional responses. These results suggest that only alpha 2-adrenoceptors in the agonist state (i.e. number of binding sites for [3H]clonidine) are modulated during the development of the heroin withdrawal syndrome.</description><identifier>ISSN: 0014-2999</identifier><identifier>DOI: 10.1016/0014-2999(85)90382-6</identifier><identifier>PMID: 2998814</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adult ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Clonidine - blood ; Clonidine - pharmacology ; Epinephrine - pharmacology ; Female ; Heroin Dependence - blood ; Humans ; In Vitro Techniques ; Kinetics ; Male ; Platelet Aggregation - drug effects ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - metabolism ; Substance Withdrawal Syndrome - blood ; Substance Withdrawal Syndrome - drug therapy</subject><ispartof>European journal of pharmacology, 1985-08, Vol.114 (3), p.365</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2998814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Sevilla, J A</creatorcontrib><creatorcontrib>Ugedo, L</creatorcontrib><creatorcontrib>Ulibarri, I</creatorcontrib><creatorcontrib>Gutierrez, M</creatorcontrib><title>Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The density of platelet alpha 2-adrenoceptors, quantitated by means of the binding of [3H]clonidine and [3H]yohimbine, and the aggregation response induced by adrenaline were investigated in thirty-two heroin addicts during spontaneous withdrawal. The number of binding sites for [3H]clonidine, but not for [3H]yohimbine, was significantly increased during withdrawal and the increase followed a time course related to the severity of the abstinence syndrome. There was a positive and significant correlation between the severity of withdrawal and the density of platelet alpha 2-adrenoceptors. Concomitantly, the adrenaline-induced platelet aggregation was potentiated. Treatment with clonidine led to significant decreases in receptor densities as well as in functional responses. These results suggest that only alpha 2-adrenoceptors in the agonist state (i.e. number of binding sites for [3H]clonidine) are modulated during the development of the heroin withdrawal syndrome.</description><subject>Adult</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Clonidine - blood</subject><subject>Clonidine - pharmacology</subject><subject>Epinephrine - pharmacology</subject><subject>Female</subject><subject>Heroin Dependence - blood</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Male</subject><subject>Platelet Aggregation - drug effects</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Receptors, Adrenergic, alpha - metabolism</subject><subject>Substance Withdrawal Syndrome - blood</subject><subject>Substance Withdrawal Syndrome - drug therapy</subject><issn>0014-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j81KxDAYRbNQxnH0DRSy1EU1_02WMvgHA7rQ9fC1-TqNtGlJMwy-vUUHVwfOhQuHkCvO7jjj5p4xrgrhnLux-tYxaUVhTsjyX5-R82n6YoxpJ_SCLGZnLVdLgu8dZOwwU-jGFqgowCeMQ41jHtJEQ6QtpmEGeB_qPFG_TyHu6CHk1ic4QEchegpNxkRzQsg9xvw707obYvAh4gU5baCb8PLIFfl8evxYvxSbt-fX9cOm2HEjc9EoLauSi0oLo7R2pa1q7WrZiMYqJ1VZgZ1rjZLWi5Ip7qTzJTIja4vcGbki13-_477q0W_HFHpI39tjrvwB8JJWFw</recordid><startdate>19850827</startdate><enddate>19850827</enddate><creator>Garcia-Sevilla, J A</creator><creator>Ugedo, L</creator><creator>Ulibarri, I</creator><creator>Gutierrez, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19850827</creationdate><title>Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine</title><author>Garcia-Sevilla, J A ; Ugedo, L ; Ulibarri, I ; Gutierrez, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g163t-f453b712b526455978bc59c3f2f849347ba80166438d27041939d7e063c8e1963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Clonidine - blood</topic><topic>Clonidine - pharmacology</topic><topic>Epinephrine - pharmacology</topic><topic>Female</topic><topic>Heroin Dependence - blood</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Male</topic><topic>Platelet Aggregation - drug effects</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Receptors, Adrenergic, alpha - metabolism</topic><topic>Substance Withdrawal Syndrome - blood</topic><topic>Substance Withdrawal Syndrome - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Sevilla, J A</creatorcontrib><creatorcontrib>Ugedo, L</creatorcontrib><creatorcontrib>Ulibarri, I</creatorcontrib><creatorcontrib>Gutierrez, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Sevilla, J A</au><au>Ugedo, L</au><au>Ulibarri, I</au><au>Gutierrez, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1985-08-27</date><risdate>1985</risdate><volume>114</volume><issue>3</issue><spage>365</spage><pages>365-</pages><issn>0014-2999</issn><abstract>The density of platelet alpha 2-adrenoceptors, quantitated by means of the binding of [3H]clonidine and [3H]yohimbine, and the aggregation response induced by adrenaline were investigated in thirty-two heroin addicts during spontaneous withdrawal. The number of binding sites for [3H]clonidine, but not for [3H]yohimbine, was significantly increased during withdrawal and the increase followed a time course related to the severity of the abstinence syndrome. There was a positive and significant correlation between the severity of withdrawal and the density of platelet alpha 2-adrenoceptors. Concomitantly, the adrenaline-induced platelet aggregation was potentiated. Treatment with clonidine led to significant decreases in receptor densities as well as in functional responses. These results suggest that only alpha 2-adrenoceptors in the agonist state (i.e. number of binding sites for [3H]clonidine) are modulated during the development of the heroin withdrawal syndrome.</abstract><cop>Netherlands</cop><pmid>2998814</pmid><doi>10.1016/0014-2999(85)90382-6</doi></addata></record> |
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| ispartof | European journal of pharmacology, 1985-08, Vol.114 (3), p.365 |
| issn | 0014-2999 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Blood Platelets - drug effects Blood Platelets - metabolism Clonidine - blood Clonidine - pharmacology Epinephrine - pharmacology Female Heroin Dependence - blood Humans In Vitro Techniques Kinetics Male Platelet Aggregation - drug effects Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - metabolism Substance Withdrawal Syndrome - blood Substance Withdrawal Syndrome - drug therapy |
| title | Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine |
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