Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Although exact causes of Parkinson disease (PD) remain enigmatic, mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuron susceptibility in both familial and sporadic PD. Two genes associated with recessive, early-onset PD encode the ubiquitin (Ub) kinase PI...

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Veröffentlicht in:	Autophagy 2018-08, Vol.14 (8), p.1404-1418
Hauptverfasser:	Hou, Xu, Fiesel, Fabienne C., Truban, Dominika, Castanedes Casey, Monica, Lin, Wen-lang, Soto, Alexandra I., Tacik, Pawel, Rousseau, Linda G., Diehl, Nancy N., Heckman, Michael G., Lorenzo-Betancor, Oswaldo, Ferrer, Isidre, Arbelo, José M., Steele, John C., Farrer, Matthew J., Cornejo-Olivas, Mario, Torres, Luis, Mata, Ignacio F., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ross, Owen A., Murray, Melissa E., Dickson, Dennis W., Springer, Wolfdieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Aging - metabolism alpha-synuclein alpha-Synuclein - metabolism Autofàgia Autophagy Biomarkers - metabolism Brain - metabolism Brain - ultrastructure Cohort Studies Envelliment Female HeLa Cells Humans lewy body disease Lewy Body Disease - metabolism Lewy Body Disease - pathology Malaltia de Parkinson Male MAPT Middle Aged Mitochondria Mitocondris Mitophagy Mutation - genetics PARK2 parkin parkinson disease Parkinson's disease phospho-ubiquitin Phosphorylation Phosphoserine - metabolism PINK1 Protein Binding Research Paper - Translational SNCA tau tau Proteins - metabolism Ubiquitin Ubiquitin - metabolism Ubiqüitina
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