Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates

An electrochemical Hofmann rearrangement is reported. With the mediation of NaBr, highly corrosive and toxic halogens are avoided. Moreover, this efficient and green approach is well compatible with a broad range of amides, including several commercial medicine derivatives, and provides direct acces...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018, Vol.16 (25), p.4615-4618
Hauptverfasser:	Li, Lijun, Xue, Mengyu, Yan, Xin, Liu, Wenmin, Xu, Kun, Zhang, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amantadine Amides Biocompatibility Carbamates (tradename) Electrochemistry Halogens Hofmann rearrangement
Online-Zugang:	Volltext
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