R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells

The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and cancer stem cells (CSCs). The transcription factor Ascl2 (Wnt target gene) is fate decider of intestinal cryptic stem cells and colon cancer stem cells. It is unclear how Wnt signaling is translated into Ascl2 exp...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2018-04, Vol.17 (8), p.1014-1025
Hauptverfasser:	Ye, Jun, Liu, Shanxi, Shang, Yangyang, Chen, Haoyuan, Wang, Rongquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Achaete scute-like 2 Autoregulation Colorectal cancer Progenitor cell Research Paper Self-renewal Wnt signaling
Online-Zugang:	Volltext
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