Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats
Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known. Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced ga...
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| Veröffentlicht in: | Pharmaceutical biology 2018-01, Vol.56 (1), p.294-301 |
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| creator | Gong, Jingwen Zhang, Zhong Zhang, Xuguang Chen, Feng Tan, Yinfeng Li, Hailong Jiang, Jie Zhang, Junqing |
| description | Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known.
Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model.
Material and methods: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0.03, 0.09, or 0.18 g/kg of the plant extract, galangin (0.2 g/kg), or bismuth potassium citrate (0.08 g/kg), once a day for 6 days. Rats in the control group received an equivalent volume of vehicle solution for 6 days. Gastric damage was evaluated by gross ulcer and histological indexes. Cyclooxygenase and non-cyclooxygenase pathway proteins were quantified by western blotting and ELISA.
Results: Alpinia officinarum extract ameliorated gastric injury in a dose-dependent manner, and 0.18 g/kg dose exhibited the best performance by reducing the gross ulcer (from 20.23 ± 1.38 to 1.66 ± 0.37) and histological (from 4.67 ± 1.03 to 0.33 ± 0.51) indexes, decreasing serum TNF-α level (14.17%), increasing serum VEGF level (1.58 times), increasing cyclooxygenase-1 level (1.25 times, p |
| doi_str_mv | 10.1080/13880209.2018.1450426 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_29781354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b1bff6a40d7140b3875609e868512bca</doaj_id><sourcerecordid>2439427695</sourcerecordid><originalsourceid>FETCH-LOGICAL-c595t-311e8be19b0243819ae1ce0274f53a4d9acbe0f2022a16e469ed13d5947e641c3</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEoh_wE0CRuHDJ4vFX4guiqkqpVIkLnC3HGW-9SuzFTgr77_Gy24py4DRj-5nXHs9bVW-ArIB05AOwriOUqBUl0K2AC8KpfFadQst5IwDk85IXptlDJ9VZzhtCiGBMvKxOqGo7YIKfVsuVc2jnXJsw1NuYs-9HrCe0dyb4POU6uvpi3PrgTUmdtz6YtEw1zgWIY42_5mTsXMdQ-zDEab9fmKYsFotDvTZ5Tt6Ww82SdiXUycz5VfXCmTHj62M8r75_vvp2-aW5_Xp9c3lx21ihxNwwAOx6BNUTylkHyiBYJLTlTjDDB2Vsj8RRQqkBiVwqHIANQvEWJQfLzqubg-4QzUZvk59M2ulovP6zEdNamzR7O6LuoXdOGk6GFjjpWdcKSRR2shNAe2uK1seD1nbpJxwshtL5-ET06Unwd3od77UERgTIIvD-KJDijwXzrCefLY6jCRiXrEuLitNWKlHQd_-gm7ikUL5KUyagjJq0baHEgbKpDC6he3wMEL03iX4wid6bRB9NUure_t3JY9WDKwrw6QD44GKazM-YxkHPZjfG5JIJ1mfN_n_Hb9F_zPY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2351042077</pqid></control><display><type>article</type><title>Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats</title><source>Taylor & Francis Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Gong, Jingwen ; Zhang, Zhong ; Zhang, Xuguang ; Chen, Feng ; Tan, Yinfeng ; Li, Hailong ; Jiang, Jie ; Zhang, Junqing</creator><creatorcontrib>Gong, Jingwen ; Zhang, Zhong ; Zhang, Xuguang ; Chen, Feng ; Tan, Yinfeng ; Li, Hailong ; Jiang, Jie ; Zhang, Junqing</creatorcontrib><description>Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known.
Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model.
Material and methods: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0.03, 0.09, or 0.18 g/kg of the plant extract, galangin (0.2 g/kg), or bismuth potassium citrate (0.08 g/kg), once a day for 6 days. Rats in the control group received an equivalent volume of vehicle solution for 6 days. Gastric damage was evaluated by gross ulcer and histological indexes. Cyclooxygenase and non-cyclooxygenase pathway proteins were quantified by western blotting and ELISA.
Results: Alpinia officinarum extract ameliorated gastric injury in a dose-dependent manner, and 0.18 g/kg dose exhibited the best performance by reducing the gross ulcer (from 20.23 ± 1.38 to 1.66 ± 0.37) and histological (from 4.67 ± 1.03 to 0.33 ± 0.51) indexes, decreasing serum TNF-α level (14.17%), increasing serum VEGF level (1.58 times), increasing cyclooxygenase-1 level (1.25 times, p < 0.001) in the gastric mucosa, and reversing indomethacin-induced changes in the expression of non-cyclooxygenase pathway proteins (p < 0.05). Galangin was less effective as an antiulcer agent than the whole extract, indicating that other components also contributed to the protective effect.
Conclusions: Alpinia officinarum extract and galangin exert antiulcer effects through cyclooxygenase and non-cyclooxygenase pathways validating use of galangin as a treatment for gastric damage.</description><identifier>ISSN: 1388-0209</identifier><identifier>ISSN: 1744-5116</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2018.1450426</identifier><identifier>PMID: 29781354</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Alpinia ; Alpinia officinarum ; animal models ; Animals ; anti-ulcer activity ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Anti-Ulcer Agents - therapeutic use ; bismuth ; blood serum ; citrates ; Citric acid ; cyclooxygenase ; Cyclooxygenase Inhibitors - toxicity ; Cyclooxygenase-1 ; dose response ; Drug dosages ; enzyme-linked immunosorbent assay ; Ethanol ; Female ; Gastric mucosa ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastrointestinal diseases ; histology ; Indomethacin ; Indomethacin - toxicity ; Inflammation Mediators - antagonists & inhibitors ; Inflammation Mediators - metabolism ; Injuries ; Laboratory animals ; Male ; mechanism of action ; Medical research ; nitric oxide ; Nonsteroidal anti-inflammatory drugs ; Oral administration ; Pharmaceuticals ; Plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; potassium ; prostaglandin synthase ; protective effect ; proteins ; Rats ; Rats, Sprague-Dawley ; Rhizomes ; Rodents ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy ; Stomach Ulcer - metabolism ; Treatment Outcome ; tumor necrosis factor-alpha ; Tumor necrosis factor-α ; Ulcers ; Vascular endothelial growth factor ; vascular endothelial growth factors ; Western blotting</subject><ispartof>Pharmaceutical biology, 2018-01, Vol.56 (1), p.294-301</ispartof><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2018</rights><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2018 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-311e8be19b0243819ae1ce0274f53a4d9acbe0f2022a16e469ed13d5947e641c3</citedby><cites>FETCH-LOGICAL-c595t-311e8be19b0243819ae1ce0274f53a4d9acbe0f2022a16e469ed13d5947e641c3</cites><orcidid>0000-0002-8622-3920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130516/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130516/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29781354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Jingwen</creatorcontrib><creatorcontrib>Zhang, Zhong</creatorcontrib><creatorcontrib>Zhang, Xuguang</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Tan, Yinfeng</creatorcontrib><creatorcontrib>Li, Hailong</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Zhang, Junqing</creatorcontrib><title>Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known.
Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model.
Material and methods: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0.03, 0.09, or 0.18 g/kg of the plant extract, galangin (0.2 g/kg), or bismuth potassium citrate (0.08 g/kg), once a day for 6 days. Rats in the control group received an equivalent volume of vehicle solution for 6 days. Gastric damage was evaluated by gross ulcer and histological indexes. Cyclooxygenase and non-cyclooxygenase pathway proteins were quantified by western blotting and ELISA.
Results: Alpinia officinarum extract ameliorated gastric injury in a dose-dependent manner, and 0.18 g/kg dose exhibited the best performance by reducing the gross ulcer (from 20.23 ± 1.38 to 1.66 ± 0.37) and histological (from 4.67 ± 1.03 to 0.33 ± 0.51) indexes, decreasing serum TNF-α level (14.17%), increasing serum VEGF level (1.58 times), increasing cyclooxygenase-1 level (1.25 times, p < 0.001) in the gastric mucosa, and reversing indomethacin-induced changes in the expression of non-cyclooxygenase pathway proteins (p < 0.05). Galangin was less effective as an antiulcer agent than the whole extract, indicating that other components also contributed to the protective effect.
Conclusions: Alpinia officinarum extract and galangin exert antiulcer effects through cyclooxygenase and non-cyclooxygenase pathways validating use of galangin as a treatment for gastric damage.</description><subject>Alpinia</subject><subject>Alpinia officinarum</subject><subject>animal models</subject><subject>Animals</subject><subject>anti-ulcer activity</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>bismuth</subject><subject>blood serum</subject><subject>citrates</subject><subject>Citric acid</subject><subject>cyclooxygenase</subject><subject>Cyclooxygenase Inhibitors - toxicity</subject><subject>Cyclooxygenase-1</subject><subject>dose response</subject><subject>Drug dosages</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Ethanol</subject><subject>Female</subject><subject>Gastric mucosa</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastrointestinal diseases</subject><subject>histology</subject><subject>Indomethacin</subject><subject>Indomethacin - toxicity</subject><subject>Inflammation Mediators - antagonists & inhibitors</subject><subject>Inflammation Mediators - metabolism</subject><subject>Injuries</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>mechanism of action</subject><subject>Medical research</subject><subject>nitric oxide</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oral administration</subject><subject>Pharmaceuticals</subject><subject>Plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>potassium</subject><subject>prostaglandin synthase</subject><subject>protective effect</subject><subject>proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rhizomes</subject><subject>Rodents</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - metabolism</subject><subject>Treatment Outcome</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor necrosis factor-α</subject><subject>Ulcers</subject><subject>Vascular endothelial growth factor</subject><subject>vascular endothelial growth factors</subject><subject>Western blotting</subject><issn>1388-0209</issn><issn>1744-5116</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEoh_wE0CRuHDJ4vFX4guiqkqpVIkLnC3HGW-9SuzFTgr77_Gy24py4DRj-5nXHs9bVW-ArIB05AOwriOUqBUl0K2AC8KpfFadQst5IwDk85IXptlDJ9VZzhtCiGBMvKxOqGo7YIKfVsuVc2jnXJsw1NuYs-9HrCe0dyb4POU6uvpi3PrgTUmdtz6YtEw1zgWIY42_5mTsXMdQ-zDEab9fmKYsFotDvTZ5Tt6Ww82SdiXUycz5VfXCmTHj62M8r75_vvp2-aW5_Xp9c3lx21ihxNwwAOx6BNUTylkHyiBYJLTlTjDDB2Vsj8RRQqkBiVwqHIANQvEWJQfLzqubg-4QzUZvk59M2ulovP6zEdNamzR7O6LuoXdOGk6GFjjpWdcKSRR2shNAe2uK1seD1nbpJxwshtL5-ET06Unwd3od77UERgTIIvD-KJDijwXzrCefLY6jCRiXrEuLitNWKlHQd_-gm7ikUL5KUyagjJq0baHEgbKpDC6he3wMEL03iX4wid6bRB9NUure_t3JY9WDKwrw6QD44GKazM-YxkHPZjfG5JIJ1mfN_n_Hb9F_zPY</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Gong, Jingwen</creator><creator>Zhang, Zhong</creator><creator>Zhang, Xuguang</creator><creator>Chen, Feng</creator><creator>Tan, Yinfeng</creator><creator>Li, Hailong</creator><creator>Jiang, Jie</creator><creator>Zhang, Junqing</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8622-3920</orcidid></search><sort><creationdate>20180101</creationdate><title>Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats</title><author>Gong, Jingwen ; Zhang, Zhong ; Zhang, Xuguang ; Chen, Feng ; Tan, Yinfeng ; Li, Hailong ; Jiang, Jie ; Zhang, Junqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-311e8be19b0243819ae1ce0274f53a4d9acbe0f2022a16e469ed13d5947e641c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alpinia</topic><topic>Alpinia officinarum</topic><topic>animal models</topic><topic>Animals</topic><topic>anti-ulcer activity</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>bismuth</topic><topic>blood serum</topic><topic>citrates</topic><topic>Citric acid</topic><topic>cyclooxygenase</topic><topic>Cyclooxygenase Inhibitors - toxicity</topic><topic>Cyclooxygenase-1</topic><topic>dose response</topic><topic>Drug dosages</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Ethanol</topic><topic>Female</topic><topic>Gastric mucosa</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastrointestinal diseases</topic><topic>histology</topic><topic>Indomethacin</topic><topic>Indomethacin - toxicity</topic><topic>Inflammation Mediators - antagonists & inhibitors</topic><topic>Inflammation Mediators - metabolism</topic><topic>Injuries</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>mechanism of action</topic><topic>Medical research</topic><topic>nitric oxide</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oral administration</topic><topic>Pharmaceuticals</topic><topic>Plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>potassium</topic><topic>prostaglandin synthase</topic><topic>protective effect</topic><topic>proteins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rhizomes</topic><topic>Rodents</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - metabolism</topic><topic>Treatment Outcome</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor necrosis factor-α</topic><topic>Ulcers</topic><topic>Vascular endothelial growth factor</topic><topic>vascular endothelial growth factors</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Jingwen</creatorcontrib><creatorcontrib>Zhang, Zhong</creatorcontrib><creatorcontrib>Zhang, Xuguang</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Tan, Yinfeng</creatorcontrib><creatorcontrib>Li, Hailong</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Zhang, Junqing</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Jingwen</au><au>Zhang, Zhong</au><au>Zhang, Xuguang</au><au>Chen, Feng</au><au>Tan, Yinfeng</au><au>Li, Hailong</au><au>Jiang, Jie</au><au>Zhang, Junqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>56</volume><issue>1</issue><spage>294</spage><epage>301</epage><pages>294-301</pages><issn>1388-0209</issn><issn>1744-5116</issn><eissn>1744-5116</eissn><abstract>Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known.
Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model.
Material and methods: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0.03, 0.09, or 0.18 g/kg of the plant extract, galangin (0.2 g/kg), or bismuth potassium citrate (0.08 g/kg), once a day for 6 days. Rats in the control group received an equivalent volume of vehicle solution for 6 days. Gastric damage was evaluated by gross ulcer and histological indexes. Cyclooxygenase and non-cyclooxygenase pathway proteins were quantified by western blotting and ELISA.
Results: Alpinia officinarum extract ameliorated gastric injury in a dose-dependent manner, and 0.18 g/kg dose exhibited the best performance by reducing the gross ulcer (from 20.23 ± 1.38 to 1.66 ± 0.37) and histological (from 4.67 ± 1.03 to 0.33 ± 0.51) indexes, decreasing serum TNF-α level (14.17%), increasing serum VEGF level (1.58 times), increasing cyclooxygenase-1 level (1.25 times, p < 0.001) in the gastric mucosa, and reversing indomethacin-induced changes in the expression of non-cyclooxygenase pathway proteins (p < 0.05). Galangin was less effective as an antiulcer agent than the whole extract, indicating that other components also contributed to the protective effect.
Conclusions: Alpinia officinarum extract and galangin exert antiulcer effects through cyclooxygenase and non-cyclooxygenase pathways validating use of galangin as a treatment for gastric damage.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>29781354</pmid><doi>10.1080/13880209.2018.1450426</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8622-3920</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Pharmaceutical biology, 2018-01, Vol.56 (1), p.294-301 |
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| language | eng |
| recordid | cdi_pubmed_primary_29781354 |
| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alpinia Alpinia officinarum animal models Animals anti-ulcer activity Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use bismuth blood serum citrates Citric acid cyclooxygenase Cyclooxygenase Inhibitors - toxicity Cyclooxygenase-1 dose response Drug dosages enzyme-linked immunosorbent assay Ethanol Female Gastric mucosa Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastrointestinal diseases histology Indomethacin Indomethacin - toxicity Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Injuries Laboratory animals Male mechanism of action Medical research nitric oxide Nonsteroidal anti-inflammatory drugs Oral administration Pharmaceuticals Plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use potassium prostaglandin synthase protective effect proteins Rats Rats, Sprague-Dawley Rhizomes Rodents Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - metabolism Treatment Outcome tumor necrosis factor-alpha Tumor necrosis factor-α Ulcers Vascular endothelial growth factor vascular endothelial growth factors Western blotting |
| title | Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T17%3A40%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20and%20possible%20mechanisms%20of%20Alpinia%20officinarum%20ethanol%20extract%20on%20indomethacin-induced%20gastric%20injury%20in%20rats&rft.jtitle=Pharmaceutical%20biology&rft.au=Gong,%20Jingwen&rft.date=2018-01-01&rft.volume=56&rft.issue=1&rft.spage=294&rft.epage=301&rft.pages=294-301&rft.issn=1388-0209&rft.eissn=1744-5116&rft_id=info:doi/10.1080/13880209.2018.1450426&rft_dat=%3Cproquest_pubme%3E2439427695%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2351042077&rft_id=info:pmid/29781354&rft_doaj_id=oai_doaj_org_article_b1bff6a40d7140b3875609e868512bca&rfr_iscdi=true |