Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions
Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16 is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16 in sera from women with no squamous intraepi...
Gespeichert in:
| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2018-05, Vol.35 (6), p.93 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | 93 |
| container_title | Medical oncology (Northwood, London, England) |
| container_volume | 35 |
| creator | Chuerduangphui, Jureeporn Pientong, Chamsai Swangphon, Piyawut Luanratanakorn, Sanguanchoke Sangkomkamhang, Ussanee Tungsiriwattana, Thumwadee Kleebkaow, Pilaiwan Burassakarn, Ati Ekalaksananan, Tipaya |
| description | Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16
is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16
in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16
antibodies in sera were determined by western blot. Among 116 samples, 69 (60%) were HPV DNA-positive. Percentages seropositive for anti-E2, -L1, and -p16
antibodies were 39.6, 22.4, and 23.3%, respectively. Anti-E2 antibody was significantly correlated with HPV DNA-positive cases. Eighty-seven women (75%) were regarded as infected with HPV, having at least one positive result from HPV DNA, L1, or E2 antibody. Antibody to p16
was associated with HPV infection (odds = 5.444, 95% CI 1.203-24.629, P = 0.028) and precancerous cervical lesions (odds = 5.132, 95% CI 1.604-16.415, P = 0.006). Interestingly, the concurrent detection of anti-E2 and -p16
antibodies was significantly associated with HPV infection (odds = 1.382, 95% CI 1.228-1.555, P = 0.044). These antibodies might be good candidate biomarkers for monitoring HPV-associated cervical lesion development to cancer. |
| doi_str_mv | 10.1007/s12032-018-1151-2 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_29744680</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>29744680</sourcerecordid><originalsourceid>FETCH-pubmed_primary_297446803</originalsourceid><addsrcrecordid>eNqFjs1KAzEUhYMgtv48gBu5LxDNzcy0nWWRSotQupDSXUlnMvZKZhJyM5UufHet1LWrs_i-czhC3KN6RKXGT4xaZVoqnEjEAqW-EEMsilJihpuBuGb-UEpjocsrMdDlOM9HEzUUX1NmX5FJ5DvwDZgu0c7XR0geZhpC9MnSL9n3rekgmEDO-dYcKPb8o9cQcASL5Ws-hU9K-1PlPVrm8-B8tZbUNbZKtobKxgNVxoGzJ8634rIxju3dOW_Ew8vs7XkuQ79rbb0NkVoTj9u_v9m_wjfTIFFq</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chuerduangphui, Jureeporn ; Pientong, Chamsai ; Swangphon, Piyawut ; Luanratanakorn, Sanguanchoke ; Sangkomkamhang, Ussanee ; Tungsiriwattana, Thumwadee ; Kleebkaow, Pilaiwan ; Burassakarn, Ati ; Ekalaksananan, Tipaya</creator><creatorcontrib>Chuerduangphui, Jureeporn ; Pientong, Chamsai ; Swangphon, Piyawut ; Luanratanakorn, Sanguanchoke ; Sangkomkamhang, Ussanee ; Tungsiriwattana, Thumwadee ; Kleebkaow, Pilaiwan ; Burassakarn, Ati ; Ekalaksananan, Tipaya</creatorcontrib><description>Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16
is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16
in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16
antibodies in sera were determined by western blot. Among 116 samples, 69 (60%) were HPV DNA-positive. Percentages seropositive for anti-E2, -L1, and -p16
antibodies were 39.6, 22.4, and 23.3%, respectively. Anti-E2 antibody was significantly correlated with HPV DNA-positive cases. Eighty-seven women (75%) were regarded as infected with HPV, having at least one positive result from HPV DNA, L1, or E2 antibody. Antibody to p16
was associated with HPV infection (odds = 5.444, 95% CI 1.203-24.629, P = 0.028) and precancerous cervical lesions (odds = 5.132, 95% CI 1.604-16.415, P = 0.006). Interestingly, the concurrent detection of anti-E2 and -p16
antibodies was significantly associated with HPV infection (odds = 1.382, 95% CI 1.228-1.555, P = 0.044). These antibodies might be good candidate biomarkers for monitoring HPV-associated cervical lesion development to cancer.</description><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-018-1151-2</identifier><identifier>PMID: 29744680</identifier><language>eng</language><publisher>United States</publisher><subject>Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Capsid Proteins - immunology ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - immunology ; Cervical Intraepithelial Neoplasia - blood ; Cervical Intraepithelial Neoplasia - immunology ; Cyclin-Dependent Kinase Inhibitor p16 - immunology ; DNA, Viral - isolation & purification ; DNA-Binding Proteins - immunology ; Female ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - immunology ; Humans ; Neoplasm Grading ; Oncogene Proteins, Viral - immunology ; Papillomavirus Infections - blood ; Papillomavirus Infections - immunology ; Seroepidemiologic Studies ; Uterine Cervical Neoplasms - blood ; Uterine Cervical Neoplasms - immunology ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - virology</subject><ispartof>Medical oncology (Northwood, London, England), 2018-05, Vol.35 (6), p.93</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2406-2356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29744680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chuerduangphui, Jureeporn</creatorcontrib><creatorcontrib>Pientong, Chamsai</creatorcontrib><creatorcontrib>Swangphon, Piyawut</creatorcontrib><creatorcontrib>Luanratanakorn, Sanguanchoke</creatorcontrib><creatorcontrib>Sangkomkamhang, Ussanee</creatorcontrib><creatorcontrib>Tungsiriwattana, Thumwadee</creatorcontrib><creatorcontrib>Kleebkaow, Pilaiwan</creatorcontrib><creatorcontrib>Burassakarn, Ati</creatorcontrib><creatorcontrib>Ekalaksananan, Tipaya</creatorcontrib><title>Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><description>Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16
is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16
in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16
antibodies in sera were determined by western blot. Among 116 samples, 69 (60%) were HPV DNA-positive. Percentages seropositive for anti-E2, -L1, and -p16
antibodies were 39.6, 22.4, and 23.3%, respectively. Anti-E2 antibody was significantly correlated with HPV DNA-positive cases. Eighty-seven women (75%) were regarded as infected with HPV, having at least one positive result from HPV DNA, L1, or E2 antibody. Antibody to p16
was associated with HPV infection (odds = 5.444, 95% CI 1.203-24.629, P = 0.028) and precancerous cervical lesions (odds = 5.132, 95% CI 1.604-16.415, P = 0.006). Interestingly, the concurrent detection of anti-E2 and -p16
antibodies was significantly associated with HPV infection (odds = 1.382, 95% CI 1.228-1.555, P = 0.044). These antibodies might be good candidate biomarkers for monitoring HPV-associated cervical lesion development to cancer.</description><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Capsid Proteins - immunology</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Cervical Intraepithelial Neoplasia - blood</subject><subject>Cervical Intraepithelial Neoplasia - immunology</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - immunology</subject><subject>DNA, Viral - isolation & purification</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Female</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 16 - immunology</subject><subject>Humans</subject><subject>Neoplasm Grading</subject><subject>Oncogene Proteins, Viral - immunology</subject><subject>Papillomavirus Infections - blood</subject><subject>Papillomavirus Infections - immunology</subject><subject>Seroepidemiologic Studies</subject><subject>Uterine Cervical Neoplasms - blood</subject><subject>Uterine Cervical Neoplasms - immunology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs1KAzEUhYMgtv48gBu5LxDNzcy0nWWRSotQupDSXUlnMvZKZhJyM5UufHet1LWrs_i-czhC3KN6RKXGT4xaZVoqnEjEAqW-EEMsilJihpuBuGb-UEpjocsrMdDlOM9HEzUUX1NmX5FJ5DvwDZgu0c7XR0geZhpC9MnSL9n3rekgmEDO-dYcKPb8o9cQcASL5Ws-hU9K-1PlPVrm8-B8tZbUNbZKtobKxgNVxoGzJ8634rIxju3dOW_Ew8vs7XkuQ79rbb0NkVoTj9u_v9m_wjfTIFFq</recordid><startdate>20180509</startdate><enddate>20180509</enddate><creator>Chuerduangphui, Jureeporn</creator><creator>Pientong, Chamsai</creator><creator>Swangphon, Piyawut</creator><creator>Luanratanakorn, Sanguanchoke</creator><creator>Sangkomkamhang, Ussanee</creator><creator>Tungsiriwattana, Thumwadee</creator><creator>Kleebkaow, Pilaiwan</creator><creator>Burassakarn, Ati</creator><creator>Ekalaksananan, Tipaya</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-2406-2356</orcidid></search><sort><creationdate>20180509</creationdate><title>Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions</title><author>Chuerduangphui, Jureeporn ; Pientong, Chamsai ; Swangphon, Piyawut ; Luanratanakorn, Sanguanchoke ; Sangkomkamhang, Ussanee ; Tungsiriwattana, Thumwadee ; Kleebkaow, Pilaiwan ; Burassakarn, Ati ; Ekalaksananan, Tipaya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_297446803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Capsid Proteins - immunology</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Cervical Intraepithelial Neoplasia - blood</topic><topic>Cervical Intraepithelial Neoplasia - immunology</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - immunology</topic><topic>DNA, Viral - isolation & purification</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Female</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 16 - immunology</topic><topic>Humans</topic><topic>Neoplasm Grading</topic><topic>Oncogene Proteins, Viral - immunology</topic><topic>Papillomavirus Infections - blood</topic><topic>Papillomavirus Infections - immunology</topic><topic>Seroepidemiologic Studies</topic><topic>Uterine Cervical Neoplasms - blood</topic><topic>Uterine Cervical Neoplasms - immunology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chuerduangphui, Jureeporn</creatorcontrib><creatorcontrib>Pientong, Chamsai</creatorcontrib><creatorcontrib>Swangphon, Piyawut</creatorcontrib><creatorcontrib>Luanratanakorn, Sanguanchoke</creatorcontrib><creatorcontrib>Sangkomkamhang, Ussanee</creatorcontrib><creatorcontrib>Tungsiriwattana, Thumwadee</creatorcontrib><creatorcontrib>Kleebkaow, Pilaiwan</creatorcontrib><creatorcontrib>Burassakarn, Ati</creatorcontrib><creatorcontrib>Ekalaksananan, Tipaya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chuerduangphui, Jureeporn</au><au>Pientong, Chamsai</au><au>Swangphon, Piyawut</au><au>Luanratanakorn, Sanguanchoke</au><au>Sangkomkamhang, Ussanee</au><au>Tungsiriwattana, Thumwadee</au><au>Kleebkaow, Pilaiwan</au><au>Burassakarn, Ati</au><au>Ekalaksananan, Tipaya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><addtitle>Med Oncol</addtitle><date>2018-05-09</date><risdate>2018</risdate><volume>35</volume><issue>6</issue><spage>93</spage><pages>93-</pages><eissn>1559-131X</eissn><abstract>Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16
is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16
in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16
antibodies in sera were determined by western blot. Among 116 samples, 69 (60%) were HPV DNA-positive. Percentages seropositive for anti-E2, -L1, and -p16
antibodies were 39.6, 22.4, and 23.3%, respectively. Anti-E2 antibody was significantly correlated with HPV DNA-positive cases. Eighty-seven women (75%) were regarded as infected with HPV, having at least one positive result from HPV DNA, L1, or E2 antibody. Antibody to p16
was associated with HPV infection (odds = 5.444, 95% CI 1.203-24.629, P = 0.028) and precancerous cervical lesions (odds = 5.132, 95% CI 1.604-16.415, P = 0.006). Interestingly, the concurrent detection of anti-E2 and -p16
antibodies was significantly associated with HPV infection (odds = 1.382, 95% CI 1.228-1.555, P = 0.044). These antibodies might be good candidate biomarkers for monitoring HPV-associated cervical lesion development to cancer.</abstract><cop>United States</cop><pmid>29744680</pmid><doi>10.1007/s12032-018-1151-2</doi><orcidid>https://orcid.org/0000-0003-2406-2356</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1559-131X |
| ispartof | Medical oncology (Northwood, London, England), 2018-05, Vol.35 (6), p.93 |
| issn | 1559-131X |
| language | eng |
| recordid | cdi_pubmed_primary_29744680 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Antibodies, Viral - blood Antibodies, Viral - immunology Capsid Proteins - immunology Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - immunology Cervical Intraepithelial Neoplasia - blood Cervical Intraepithelial Neoplasia - immunology Cyclin-Dependent Kinase Inhibitor p16 - immunology DNA, Viral - isolation & purification DNA-Binding Proteins - immunology Female Human papillomavirus 16 - genetics Human papillomavirus 16 - immunology Humans Neoplasm Grading Oncogene Proteins, Viral - immunology Papillomavirus Infections - blood Papillomavirus Infections - immunology Seroepidemiologic Studies Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology |
| title | Association of antibody to E2 protein of human papillomavirus and p16 INK4A with progression of HPV-infected cervical lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A37%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20antibody%20to%20E2%20protein%20of%20human%20papillomavirus%20and%20p16%20INK4A%20with%20progression%20of%20HPV-infected%20cervical%20lesions&rft.jtitle=Medical%20oncology%20(Northwood,%20London,%20England)&rft.au=Chuerduangphui,%20Jureeporn&rft.date=2018-05-09&rft.volume=35&rft.issue=6&rft.spage=93&rft.pages=93-&rft.eissn=1559-131X&rft_id=info:doi/10.1007/s12032-018-1151-2&rft_dat=%3Cpubmed%3E29744680%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/29744680&rfr_iscdi=true |