Quantitative analysis of complex drug-drug interactions (DDIs) between cerivastatin and inhibitors using physiologically based pharmacokinetic (PBPK) modeling

Cerivastatin (CER) was withdrawn from the world market because of lethal rhabdomyolysis. Coadministrations of CER and cyclosporine A (CsA) or gemfibrozil (GEM) have been reported to increase the CER blood concentration. CsA is an inhibitor of OATP1B1 and CYP3A4, and GEM and its glucuronide (GEM-glu)...

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Veröffentlicht in:	Drug metabolism and disposition 2018-04
Hauptverfasser:	Yao, Yoshiaki, Toshimoto, Kota, Kim, Soo-Jin, Yoshikado, Takashi, Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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