Angiotensin II cyclic analogs as tools to investigate AT 1 R biased signaling mechanisms

G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to di...

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Veröffentlicht in:	Biochemical pharmacology 2018-08, Vol.154, p.104
Hauptverfasser:	St-Pierre, David, Cabana, Jérôme, Holleran, Brian J, Besserer-Offroy, Élie, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre, Leduc, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - chemistry Angiotensin II - metabolism Angiotensin II - pharmacology Angiotensin II Type 1 Receptor Blockers - chemistry Angiotensin II Type 1 Receptor Blockers - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Dose-Response Relationship, Drug HEK293 Cells Humans Receptor, Angiotensin, Type 1 - chemistry Receptor, Angiotensin, Type 1 - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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