Can Ga-68 DOTA Peptides be Potential Radiotracers for PET Imaging of Spleen?

Can Ga-68 DOTA Peptides be Potential Radiotracers for PET Imaging of Spleen?

On radionuclide somatostatin receptor (SSTR) imaging studies spleen shows very high uptake which is a physiological finding. Reducing intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies we incidentally recognized that Gallium-6...

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Veröffentlicht in:Journal of nuclear medicine technology 2018-06
Hauptverfasser: Sarikaya, Ismet, Elgazzar, Abdelhamid, Sarikaya, Ali, Alnafisi, Naheel, Alenezi, Saud
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Elgazzar, Abdelhamid
Sarikaya, Ali
Alnafisi, Naheel
Alenezi, Saud
description On radionuclide somatostatin receptor (SSTR) imaging studies spleen shows very high uptake which is a physiological finding. Reducing intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies we incidentally recognized that Gallium-68 (Ga-68) DOTANOC positron emission tomography (PET) provides higher resolution splenic images as compared to In-111 Octreotide single photon emission computed tomography (SPECT). Autoradiography and immunohistochemistry studies have shown that SSTRs are mainly located in the red pulp of the spleen. Distribution of Ga-68 DOTANOC in the spleen appears to be correlating with the distribution of red pulp. In this article we will present Ga-68 DOTANOC PET/CT spleen images of our patients.
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Reducing intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies we incidentally recognized that Gallium-68 (Ga-68) DOTANOC positron emission tomography (PET) provides higher resolution splenic images as compared to In-111 Octreotide single photon emission computed tomography (SPECT). Autoradiography and immunohistochemistry studies have shown that SSTRs are mainly located in the red pulp of the spleen. Distribution of Ga-68 DOTANOC in the spleen appears to be correlating with the distribution of red pulp. 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title Can Ga-68 DOTA Peptides be Potential Radiotracers for PET Imaging of Spleen?
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