Identification of multi-target inhibitors of leukotriene and prostaglandin E 2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7

Leukotrienes (LTs) and prostaglandin (PG)E are enzymatically produced from arachidonic acid and represent highly bioactive lipid mediators with pro-inflammatory functions. Here, we report on novel multi-target inhibitors that potently and dually interfere with 5-lipoxygenase-activating protein (FLAP...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-03, Vol.150, p.876
Hauptverfasser:	Gür, Zehra Tuğçe, Çalışkan, Burcu, Garscha, UIrike, Olgaç, Abdurrahman, Schubert, Ulrich S, Gerstmeier, Jana, Werz, Oliver, Banoglu, Erden
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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