A voltammetric immunosensor for clenbuterol based on the use of a MoS 2 -AuPt nanocomposite
An ultrasensitive immunosensor for the direct detection of the illegally used livestock feed clebuterol (CLB) is described. It is based on the use of a glassy carbon electrode modified with an MoS -AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS -AuPt accelerates electron t...
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Veröffentlicht in: | Mikrochimica acta (1966) 2018-03, Vol.185 (4), p.209 |
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creator | Ji, Renyue Chen, Shuai Xu, Wei Qin, Zhen Qiu, Jing Fu Li, Chao Rui |
description | An ultrasensitive immunosensor for the direct detection of the illegally used livestock feed clebuterol (CLB) is described. It is based on the use of a glassy carbon electrode modified with an MoS
-AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS
-AuPt accelerates electron transfer, and this leads to a sharp increase in the electrochemical signal for the electrochemical probe hydrogen peroxide. Differential pulse voltammetry was used to record the current signal at a peak potential of -0.18 V (vs SCE). Under optimal conditions, the electrode has a linear response in the 10 pg·mL
to 100 ng·mL
CLB concentration range and a 6.9 pg·mL
detection limit (based on the 3σ criterium). This immunosensor is sensitive, highly specific and acceptably reproducible, and thus represents a valuable tool for the determination of CLB in pork. Graphical abstract Schematic of a voltammetric immunosensor for the determination of clenbuterol (CLB) based on the use of a nanocomposite prepared from molybdenum disulfide and a gold-platinum alloy (MoS
-AuPt), and making use of the biotin-streptavidin system. |
format | Article |
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-AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS
-AuPt accelerates electron transfer, and this leads to a sharp increase in the electrochemical signal for the electrochemical probe hydrogen peroxide. Differential pulse voltammetry was used to record the current signal at a peak potential of -0.18 V (vs SCE). Under optimal conditions, the electrode has a linear response in the 10 pg·mL
to 100 ng·mL
CLB concentration range and a 6.9 pg·mL
detection limit (based on the 3σ criterium). This immunosensor is sensitive, highly specific and acceptably reproducible, and thus represents a valuable tool for the determination of CLB in pork. Graphical abstract Schematic of a voltammetric immunosensor for the determination of clenbuterol (CLB) based on the use of a nanocomposite prepared from molybdenum disulfide and a gold-platinum alloy (MoS
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-AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS
-AuPt accelerates electron transfer, and this leads to a sharp increase in the electrochemical signal for the electrochemical probe hydrogen peroxide. Differential pulse voltammetry was used to record the current signal at a peak potential of -0.18 V (vs SCE). Under optimal conditions, the electrode has a linear response in the 10 pg·mL
to 100 ng·mL
CLB concentration range and a 6.9 pg·mL
detection limit (based on the 3σ criterium). This immunosensor is sensitive, highly specific and acceptably reproducible, and thus represents a valuable tool for the determination of CLB in pork. Graphical abstract Schematic of a voltammetric immunosensor for the determination of clenbuterol (CLB) based on the use of a nanocomposite prepared from molybdenum disulfide and a gold-platinum alloy (MoS
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-AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS
-AuPt accelerates electron transfer, and this leads to a sharp increase in the electrochemical signal for the electrochemical probe hydrogen peroxide. Differential pulse voltammetry was used to record the current signal at a peak potential of -0.18 V (vs SCE). Under optimal conditions, the electrode has a linear response in the 10 pg·mL
to 100 ng·mL
CLB concentration range and a 6.9 pg·mL
detection limit (based on the 3σ criterium). This immunosensor is sensitive, highly specific and acceptably reproducible, and thus represents a valuable tool for the determination of CLB in pork. Graphical abstract Schematic of a voltammetric immunosensor for the determination of clenbuterol (CLB) based on the use of a nanocomposite prepared from molybdenum disulfide and a gold-platinum alloy (MoS
-AuPt), and making use of the biotin-streptavidin system.</abstract><cop>Austria</cop><pmid>29594630</pmid><orcidid>https://orcid.org/0000-0002-5959-032X</orcidid></addata></record> |
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title | A voltammetric immunosensor for clenbuterol based on the use of a MoS 2 -AuPt nanocomposite |
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