A voltammetric immunosensor for clenbuterol based on the use of a MoS 2 -AuPt nanocomposite

An ultrasensitive immunosensor for the direct detection of the illegally used livestock feed clebuterol (CLB) is described. It is based on the use of a glassy carbon electrode modified with an MoS -AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS -AuPt accelerates electron t...

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Veröffentlicht in:Mikrochimica acta (1966) 2018-03, Vol.185 (4), p.209
Hauptverfasser: Ji, Renyue, Chen, Shuai, Xu, Wei, Qin, Zhen, Qiu, Jing Fu, Li, Chao Rui
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container_title Mikrochimica acta (1966)
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creator Ji, Renyue
Chen, Shuai
Xu, Wei
Qin, Zhen
Qiu, Jing Fu
Li, Chao Rui
description An ultrasensitive immunosensor for the direct detection of the illegally used livestock feed clebuterol (CLB) is described. It is based on the use of a glassy carbon electrode modified with an MoS -AuPt nanocomposite and on biotin-streptavidin interaction. The use of MoS -AuPt accelerates electron transfer, and this leads to a sharp increase in the electrochemical signal for the electrochemical probe hydrogen peroxide. Differential pulse voltammetry was used to record the current signal at a peak potential of -0.18 V (vs SCE). Under optimal conditions, the electrode has a linear response in the 10 pg·mL to 100 ng·mL CLB concentration range and a 6.9 pg·mL detection limit (based on the 3σ criterium). This immunosensor is sensitive, highly specific and acceptably reproducible, and thus represents a valuable tool for the determination of CLB in pork. Graphical abstract Schematic of a voltammetric immunosensor for the determination of clenbuterol (CLB) based on the use of a nanocomposite prepared from molybdenum disulfide and a gold-platinum alloy (MoS -AuPt), and making use of the biotin-streptavidin system.
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title A voltammetric immunosensor for clenbuterol based on the use of a MoS 2 -AuPt nanocomposite
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