Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family
To investigate if leptin shares in vivo activities with interleukin (IL)-6 family cytokines, it was tested in normal mice for the ability, after a single injection, to induce the acute-phase protein serum amyloid A, to potentiate the induction by IL-1 of serum corticosterone and IL-6, and to inhibit...
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Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-09, Vol.275 (3), p.R913 |
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container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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creator | Agnello, Davide Meazza, Cristina Rowan, Christopher G Villa, Pia Ghezzi, Pietro Senaldi, Giorgio |
description | To investigate if leptin shares in vivo activities with interleukin (IL)-6 family cytokines, it was tested in normal mice for the ability, after a single injection, to induce the acute-phase protein serum amyloid A, to potentiate the induction by IL-1 of serum corticosterone and IL-6, and to inhibit the induction by lipopolysaccharide of serum tumor necrosis factor and, after seven daily injections, to cause body weight loss and to change peripheral blood cell counts. At a 0.5 mg/kg dose, leptin caused body weight loss but did not show any of the other activities above. At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity. In addition to causing body weight loss, leptin shows only some of the in vivo activities typical of IL-6 family cytokines and only if used at a dose that exceeds the one sufficient to affect body weight. In vivo, leptin seems to chiefly control body weight and not inflammatory or hematopoietic processes. |
doi_str_mv | 10.1152/ajpregu.1998.275.3.R913 |
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At a 0.5 mg/kg dose, leptin caused body weight loss but did not show any of the other activities above. At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity. In addition to causing body weight loss, leptin shows only some of the in vivo activities typical of IL-6 family cytokines and only if used at a dose that exceeds the one sufficient to affect body weight. In vivo, leptin seems to chiefly control body weight and not inflammatory or hematopoietic processes.</description><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1998.275.3.R913</identifier><identifier>PMID: 29587002</identifier><language>eng</language><publisher>United States</publisher><ispartof>American journal of physiology. 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title | Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family |
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