A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multi-Drug Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport

Multi-drug resistance (MDR) is a common limitation for the clinical use of microtubule-targeting chemotherapeutic agents and it is the main factor for poor prognoses in cancer therapy. Here, we report on deoxypodophyllotoxin (DPT), a promising microtubule inhibitor in phase I, as a promising candida...

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Veröffentlicht in:	Drug metabolism and disposition 2018-03
Hauptverfasser:	Zang, Xiaojie, Wang, Guangji, Cai, Qinngyun, Zheng, Xiao, Zhang, Jingwei, Chen, Qianying, Wu, Baojin, Zhu, Xiong, Hao, Haiping, Zhou, Fang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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