Alterations in System x c - Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

Nrf2 (nuclear factor erythroid 2-related factor 2), a transcription factor that controls expression of several proteins that are related to cellular antioxidant capacity, such as the subunit xCT of the system x , is dysregulated in diabetes. Recently, it was described that system x is decreased in t...

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Veröffentlicht in:	Molecular neurobiology 2018-10, Vol.55 (10), p.7941
Hauptverfasser:	Carpi-Santos, Raul, Calaza, Karin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems, Acidic - genetics Amino Acid Transport Systems, Acidic - metabolism Animals Antioxidants - metabolism Blood Glucose - metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - metabolism Glutathione - metabolism Male NF-E2-Related Factor 2 - metabolism Oxidative Stress Promoter Regions, Genetic - genetics Protein Binding Protein Subunits - metabolism Rats, Wistar Reactive Oxygen Species - metabolism Response Elements - genetics Retina - metabolism Time Factors
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