Regulatory mechanisms in cytotoxic T lymphocyte development: II. Dissociation of in vitro cytotoxic T-lymphocyte and suppressor T-cell activities with l-ornithine

l-ornithine was found to differentially affect the induction of allospecific cytotoxic T lymphocytes (CTL) and suppressor T cells (Ts). At a concentration of 10 m M ornithine inhibited the development of CTL in a mixed-leukocyte culture (MLC). This same population of cells suppressed the generation...

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