Successive addition of two different Grignard reagents to nitriles: access to α,α-disubstituted propargylamine derivatives

The successive addition of two different Grignard reagents to acyl cyanohydrins was performed with success by taking advantage of the low reactivity of alkynyl Grignard reagents. The experimental conditions were adjusted so that they were not reactive during the first addition step, but reactive onl...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018-02, Vol.16 (9), p.1519-1526
Hauptverfasser:	Caillé, Julien, Boukattaya, Fatma, Boeda, Fabien, Pearson-Long, Morwenna S. M, Ammar, Houcine, Bertus, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Chemical Sciences Cyanide Nitriles Organic chemistry Reagents
Online-Zugang:	Volltext
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