Degradation of cartilage by macrophages in culture: Evidence for the involvement of an enzyme which is associated with the cell surface

A cell culture system is described in which purified mononuclear phagocytes may be cultured with a cartilage substrate which is radiolabelled in its proteoglycan. Resident mouse peritoneal macrophages degraded this substrate, and did so more avidly if cultured in direct contact with it. There was no...

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