Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome
Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on...
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| Veröffentlicht in: | Food & function 2018-02, Vol.9 (2), p.128-137 |
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| creator | Jiang, Tiemin Liu, Bin Li, Jufang Dong, Xueyan Lin, Man Zhang, Minghui Zhao, Junying Dai, Yaohua Chen, Lijun |
| description | Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on the gut microbiome of infants. This study aimed at examining possible effects of sn-2 FAs of human milk on the gut microbial development of breastfeeding babies. Sn-2 FAs and intestinal microbiota were assessed by GC-MS and high-throughput 16S rRNA sequencing, respectively. The results showed that breast milk from mothers in China contained ten major sn-2 FAs dominated by palmitic acid (C
16:0
, 54.42%), oleic acid (C
18:1
n-9, 14.95%), linoleic acid (LA, C
18:2
n-6, 12.81%), myristic acid (C
14:0
, 4.50%) and C
12:0
(3.17%). Total long chain unsaturated fatty acids (LCUFA) decreased from colostrum to mature milk, while total saturated fatty acids (SFA) showed no significant difference during lactation. A significant association between sn-2 FAs in milk and infant gut microbiota was found between decanoic acid (C
10:0
), myristic acid (C
14:0
), stearic acid (C
18:0
), C
16:0
, arachidonic acid (AA, C
20:4
n-6), docosahexaenoic acid (DHA, C
22:6
n-3) with
Bacteroides
, Enterobacteriaceae,
Veillonella
,
Streptococcus
, and
Clostridium
. These microbes were involved in short-chain fatty acid (SCFA) production and other functions, and significantly increased at 13-15 d after breastfeeding was initiated. C
16:0
and DHA were relevant to most of the microbes. This study demonstrated the relatively steady profiles of sn-2 FAs in breast milk and gut microbiota of infants, together with their correlation during the breastfeeding period. The above results provided important information for designing the configuration of FAs in next-generation formulas for Chinese infants.
Increasing evidence shows that host diet and gut microbes are related. |
| doi_str_mv | 10.1039/c7fo00088j |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_29349441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1989606300</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-74377811dfab5d86e2d791c8d3e1d7857d60c2a211d2bc4f312858e92e0295f93</originalsourceid><addsrcrecordid>eNpd0c9LHDEUB_BQFFdWL96VgBcpTM2PmUlylKX2BwteLPQ2ZJIXmnUmWSfZFv97s113BU9JeB8eL9-H0AUlXyjh6tYIFwkhUq4-oVNGala1Dfl9tL_Xqp2h85RWxRSupJInaMYUr1Vd01MU71KKxuvsY8A95H8AAadQMex0zi9YG2_xeorOD5BwdLifQKeMRz88YR0stvAXhrgeIeRtOf8B7IPT5eVDhpR90EPRZoq9jyOcoWOnhwTnb-cc_br_-rj4Xi0fvv1Y3C0rw4XMlai5EJJS63TfWNkCs0JRIy0HaoVshG2JYZoVwXpTO06ZbCQoBoSpxik-Rze7vmX2502Zoxt9MjAMOkDcpI6WJFrS8hLKHF1_oKu4mcrYqWOEEtkqqrbq806Vn6Q0gevWkx_19NJR0m030S3E_cP_Tfws-Oqt5aYfwR7oPvcCLndgSuZQfV8lfwXbco0M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2010869190</pqid></control><display><type>article</type><title>Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Jiang, Tiemin ; Liu, Bin ; Li, Jufang ; Dong, Xueyan ; Lin, Man ; Zhang, Minghui ; Zhao, Junying ; Dai, Yaohua ; Chen, Lijun</creator><creatorcontrib>Jiang, Tiemin ; Liu, Bin ; Li, Jufang ; Dong, Xueyan ; Lin, Man ; Zhang, Minghui ; Zhao, Junying ; Dai, Yaohua ; Chen, Lijun</creatorcontrib><description>Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on the gut microbiome of infants. This study aimed at examining possible effects of sn-2 FAs of human milk on the gut microbial development of breastfeeding babies. Sn-2 FAs and intestinal microbiota were assessed by GC-MS and high-throughput 16S rRNA sequencing, respectively. The results showed that breast milk from mothers in China contained ten major sn-2 FAs dominated by palmitic acid (C
16:0
, 54.42%), oleic acid (C
18:1
n-9, 14.95%), linoleic acid (LA, C
18:2
n-6, 12.81%), myristic acid (C
14:0
, 4.50%) and C
12:0
(3.17%). Total long chain unsaturated fatty acids (LCUFA) decreased from colostrum to mature milk, while total saturated fatty acids (SFA) showed no significant difference during lactation. A significant association between sn-2 FAs in milk and infant gut microbiota was found between decanoic acid (C
10:0
), myristic acid (C
14:0
), stearic acid (C
18:0
), C
16:0
, arachidonic acid (AA, C
20:4
n-6), docosahexaenoic acid (DHA, C
22:6
n-3) with
Bacteroides
, Enterobacteriaceae,
Veillonella
,
Streptococcus
, and
Clostridium
. These microbes were involved in short-chain fatty acid (SCFA) production and other functions, and significantly increased at 13-15 d after breastfeeding was initiated. C
16:0
and DHA were relevant to most of the microbes. This study demonstrated the relatively steady profiles of sn-2 FAs in breast milk and gut microbiota of infants, together with their correlation during the breastfeeding period. The above results provided important information for designing the configuration of FAs in next-generation formulas for Chinese infants.
Increasing evidence shows that host diet and gut microbes are related.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/c7fo00088j</identifier><identifier>PMID: 29349441</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Arachidonic acid ; Babies ; Baby foods ; Breast ; Breast feeding ; Breast milk ; Breastfeeding & lactation ; Chains ; Colostrum ; Digestive system ; Docosahexaenoic acid ; Fatty acids ; Gastrointestinal tract ; Infants ; Intestinal microflora ; Intestine ; Lactation ; Linoleic acid ; Microbiomes ; Microbiota ; Microorganisms ; Milk ; Oleic acid ; Palmitic acid ; rRNA 16S ; Stearic acid ; Triglycerides</subject><ispartof>Food & function, 2018-02, Vol.9 (2), p.128-137</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-74377811dfab5d86e2d791c8d3e1d7857d60c2a211d2bc4f312858e92e0295f93</citedby><cites>FETCH-LOGICAL-c378t-74377811dfab5d86e2d791c8d3e1d7857d60c2a211d2bc4f312858e92e0295f93</cites><orcidid>0000-0002-6100-1870 ; 0000-0002-8157-3833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29349441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Tiemin</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Li, Jufang</creatorcontrib><creatorcontrib>Dong, Xueyan</creatorcontrib><creatorcontrib>Lin, Man</creatorcontrib><creatorcontrib>Zhang, Minghui</creatorcontrib><creatorcontrib>Zhao, Junying</creatorcontrib><creatorcontrib>Dai, Yaohua</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><title>Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on the gut microbiome of infants. This study aimed at examining possible effects of sn-2 FAs of human milk on the gut microbial development of breastfeeding babies. Sn-2 FAs and intestinal microbiota were assessed by GC-MS and high-throughput 16S rRNA sequencing, respectively. The results showed that breast milk from mothers in China contained ten major sn-2 FAs dominated by palmitic acid (C
16:0
, 54.42%), oleic acid (C
18:1
n-9, 14.95%), linoleic acid (LA, C
18:2
n-6, 12.81%), myristic acid (C
14:0
, 4.50%) and C
12:0
(3.17%). Total long chain unsaturated fatty acids (LCUFA) decreased from colostrum to mature milk, while total saturated fatty acids (SFA) showed no significant difference during lactation. A significant association between sn-2 FAs in milk and infant gut microbiota was found between decanoic acid (C
10:0
), myristic acid (C
14:0
), stearic acid (C
18:0
), C
16:0
, arachidonic acid (AA, C
20:4
n-6), docosahexaenoic acid (DHA, C
22:6
n-3) with
Bacteroides
, Enterobacteriaceae,
Veillonella
,
Streptococcus
, and
Clostridium
. These microbes were involved in short-chain fatty acid (SCFA) production and other functions, and significantly increased at 13-15 d after breastfeeding was initiated. C
16:0
and DHA were relevant to most of the microbes. This study demonstrated the relatively steady profiles of sn-2 FAs in breast milk and gut microbiota of infants, together with their correlation during the breastfeeding period. The above results provided important information for designing the configuration of FAs in next-generation formulas for Chinese infants.
Increasing evidence shows that host diet and gut microbes are related.</description><subject>Arachidonic acid</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Breast</subject><subject>Breast feeding</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Chains</subject><subject>Colostrum</subject><subject>Digestive system</subject><subject>Docosahexaenoic acid</subject><subject>Fatty acids</subject><subject>Gastrointestinal tract</subject><subject>Infants</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Lactation</subject><subject>Linoleic acid</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Milk</subject><subject>Oleic acid</subject><subject>Palmitic acid</subject><subject>rRNA 16S</subject><subject>Stearic acid</subject><subject>Triglycerides</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpd0c9LHDEUB_BQFFdWL96VgBcpTM2PmUlylKX2BwteLPQ2ZJIXmnUmWSfZFv97s113BU9JeB8eL9-H0AUlXyjh6tYIFwkhUq4-oVNGala1Dfl9tL_Xqp2h85RWxRSupJInaMYUr1Vd01MU71KKxuvsY8A95H8AAadQMex0zi9YG2_xeorOD5BwdLifQKeMRz88YR0stvAXhrgeIeRtOf8B7IPT5eVDhpR90EPRZoq9jyOcoWOnhwTnb-cc_br_-rj4Xi0fvv1Y3C0rw4XMlai5EJJS63TfWNkCs0JRIy0HaoVshG2JYZoVwXpTO06ZbCQoBoSpxik-Rze7vmX2502Zoxt9MjAMOkDcpI6WJFrS8hLKHF1_oKu4mcrYqWOEEtkqqrbq806Vn6Q0gevWkx_19NJR0m030S3E_cP_Tfws-Oqt5aYfwR7oPvcCLndgSuZQfV8lfwXbco0M</recordid><startdate>20180221</startdate><enddate>20180221</enddate><creator>Jiang, Tiemin</creator><creator>Liu, Bin</creator><creator>Li, Jufang</creator><creator>Dong, Xueyan</creator><creator>Lin, Man</creator><creator>Zhang, Minghui</creator><creator>Zhao, Junying</creator><creator>Dai, Yaohua</creator><creator>Chen, Lijun</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6100-1870</orcidid><orcidid>https://orcid.org/0000-0002-8157-3833</orcidid></search><sort><creationdate>20180221</creationdate><title>Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome</title><author>Jiang, Tiemin ; Liu, Bin ; Li, Jufang ; Dong, Xueyan ; Lin, Man ; Zhang, Minghui ; Zhao, Junying ; Dai, Yaohua ; Chen, Lijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-74377811dfab5d86e2d791c8d3e1d7857d60c2a211d2bc4f312858e92e0295f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arachidonic acid</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Breast</topic><topic>Breast feeding</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Chains</topic><topic>Colostrum</topic><topic>Digestive system</topic><topic>Docosahexaenoic acid</topic><topic>Fatty acids</topic><topic>Gastrointestinal tract</topic><topic>Infants</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Lactation</topic><topic>Linoleic acid</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Milk</topic><topic>Oleic acid</topic><topic>Palmitic acid</topic><topic>rRNA 16S</topic><topic>Stearic acid</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Tiemin</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Li, Jufang</creatorcontrib><creatorcontrib>Dong, Xueyan</creatorcontrib><creatorcontrib>Lin, Man</creatorcontrib><creatorcontrib>Zhang, Minghui</creatorcontrib><creatorcontrib>Zhao, Junying</creatorcontrib><creatorcontrib>Dai, Yaohua</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Tiemin</au><au>Liu, Bin</au><au>Li, Jufang</au><au>Dong, Xueyan</au><au>Lin, Man</au><au>Zhang, Minghui</au><au>Zhao, Junying</au><au>Dai, Yaohua</au><au>Chen, Lijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2018-02-21</date><risdate>2018</risdate><volume>9</volume><issue>2</issue><spage>128</spage><epage>137</epage><pages>128-137</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on the gut microbiome of infants. This study aimed at examining possible effects of sn-2 FAs of human milk on the gut microbial development of breastfeeding babies. Sn-2 FAs and intestinal microbiota were assessed by GC-MS and high-throughput 16S rRNA sequencing, respectively. The results showed that breast milk from mothers in China contained ten major sn-2 FAs dominated by palmitic acid (C
16:0
, 54.42%), oleic acid (C
18:1
n-9, 14.95%), linoleic acid (LA, C
18:2
n-6, 12.81%), myristic acid (C
14:0
, 4.50%) and C
12:0
(3.17%). Total long chain unsaturated fatty acids (LCUFA) decreased from colostrum to mature milk, while total saturated fatty acids (SFA) showed no significant difference during lactation. A significant association between sn-2 FAs in milk and infant gut microbiota was found between decanoic acid (C
10:0
), myristic acid (C
14:0
), stearic acid (C
18:0
), C
16:0
, arachidonic acid (AA, C
20:4
n-6), docosahexaenoic acid (DHA, C
22:6
n-3) with
Bacteroides
, Enterobacteriaceae,
Veillonella
,
Streptococcus
, and
Clostridium
. These microbes were involved in short-chain fatty acid (SCFA) production and other functions, and significantly increased at 13-15 d after breastfeeding was initiated. C
16:0
and DHA were relevant to most of the microbes. This study demonstrated the relatively steady profiles of sn-2 FAs in breast milk and gut microbiota of infants, together with their correlation during the breastfeeding period. The above results provided important information for designing the configuration of FAs in next-generation formulas for Chinese infants.
Increasing evidence shows that host diet and gut microbes are related.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29349441</pmid><doi>10.1039/c7fo00088j</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6100-1870</orcidid><orcidid>https://orcid.org/0000-0002-8157-3833</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2018-02, Vol.9 (2), p.128-137 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_pubmed_primary_29349441 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Arachidonic acid Babies Baby foods Breast Breast feeding Breast milk Breastfeeding & lactation Chains Colostrum Digestive system Docosahexaenoic acid Fatty acids Gastrointestinal tract Infants Intestinal microflora Intestine Lactation Linoleic acid Microbiomes Microbiota Microorganisms Milk Oleic acid Palmitic acid rRNA 16S Stearic acid Triglycerides |
| title | Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome |
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