Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15

Enhancement of antibody-dependent cellular cytotoxicity (ADCC) may potentiate the antitumor efficacy of tumor-targeted monoclonal antibodies. Increasing the numbers and antitumor activity of NK cells is a promising strategy to maximize the ADCC of standard-of-care tumor-targeted antibodies. For this...

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Veröffentlicht in:	Oncoimmunology 2018-02, Vol.7 (2), p.e1393597-e1393597
Hauptverfasser:	Ochoa, Maria Carmen, Minute, Luna, López, Ascensión, Pérez-Ruiz, Elisabeth, Gomar, Celia, Vasquez, Marcos, Inoges, Susana, Etxeberria, Iñaki, Rodriguez, Inmaculada, Garasa, Saray, Mayer, Jan-Peter Andreas, Wirtz, Peter, Melero, Ignacio, Berraondo, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody-dependent cellular cytotoxicity apolipoprotein A-I cetuximab interleukin 15 NK cell Original Research scavenger receptor class B type I
Online-Zugang:	Volltext
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