MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAF V600E mutation

Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSADs and BRAF...

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Veröffentlicht in:	BMC cancer 2018-01, Vol.18 (1), p.35
Hauptverfasser:	Fennell, Lochlan J, Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara, Whitehall, Vicki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Aged Animals Biomarkers, Tumor - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Methylation - genetics Female Gene Expression Regulation, Neoplastic Genotype Humans Male Middle Aged Mutation MutL Protein Homolog 1 - genetics Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic Proto-Oncogene Proteins B-raf - genetics
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