Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent

Benzylpenicillin acts through binding with beta-lactamase enzyme and inhibiting the bacterial cell wall biosynthesis. Therefore, the radiolabeling of benzylpenicillin with lutetium-177 is expected to serve as a theranostic agent for deep-seated bacterial infections. The radiolabeling of benzylpenici...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2017-11, Vol.30 (6(Supplementary)), p.2349
Hauptverfasser:	Shahzad, Muhammad Adeel, Naqvi, Syed Ali Raza, Rasheed, Rashid, Yameen, Muhammad, Anjum, Fozia, Ahmed, Muhammad Tauqeer, Hussain, Zaib, Gillani, Syed Jawad Hussain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Drug Stability Isotope Labeling Kidney - diagnostic imaging Kidney - metabolism Liver - diagnostic imaging Liver - metabolism Lutetium - administration & dosage Lutetium - pharmacokinetics Penicillin G - administration & dosage Penicillin G - analogs & derivatives Penicillin G - pharmacokinetics Rabbits Radioisotopes - administration & dosage Radioisotopes - pharmacokinetics Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - pharmacokinetics Renal Elimination Theranostic Nanomedicine - methods Tissue Distribution Tomography, Emission-Computed, Single-Photon
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