Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β 2 -adrenergic receptor but not by AMPK

Leptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of β -adrenergic receptor (AR), the major β-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Lepti...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.15141
Hauptverfasser:	Shiuchi, Tetsuya, Toda, Chitoku, Okamoto, Shiki, Coutinho, Eulalia A, Saito, Kumiko, Miura, Shinji, Ezaki, Osamu, Minokoshi, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Glucose - metabolism Leptin - metabolism Mice Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Receptors, G-Protein-Coupled - metabolism
Online-Zugang:	Volltext
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