Coordination and redox state-dependent structural changes of the heme-based oxygen sensor Af GcHK associated with intraprotein signal transduction

The heme-based oxygen sensor histidine kinase GcHK is part of a two-component signal transduction system in bacteria. O binding to the Fe(II) heme complex of its N-terminal globin domain strongly stimulates autophosphorylation at His in its C-terminal kinase domain. The 6-coordinate heme Fe(III)-OH...

Ausführliche Beschreibung