Guanidinium-based "molecular glues" for modulation of biomolecular functions

Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strat...

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Veröffentlicht in:	Chemical Society reviews 2017-10, Vol.46 (21), p.648-6491
Hauptverfasser:	Mogaki, Rina, Hashim, P. K, Okuro, Kou, Aida, Takuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Biological activity Biomolecules Carbohydrates - chemistry Drug delivery systems Glues Guanidine - chemistry Modulation Molecular Structure Nucleic Acids - chemistry Peptides - chemistry
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