Targeting Epigenetics in Cancer

Alterations of genes regulating epigenetic processes are frequently found as cancer drivers and may cause widespread alterations of DNA methylation, histone modification patterns, or chromatin structure that disrupt normal patterns of gene expression. Because of the inherent reversibility of epigene...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 2018-01, Vol.58 (1), p.187-207
Hauptverfasser:	Bennett, Richard L, Licht, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer therapies Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use DNA methylation Epigenesis, Genetic - drug effects epigenetic readers epigenetics histone acetylation histone methylation Humans Neoplasms - drug therapy Small Molecule Libraries - pharmacology Small Molecule Libraries - therapeutic use
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