PGE 1 and E 3 show lower efficacies than E 2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors
The 2-series of prostaglandin E (PGE ) is regarded as a pro-cancer prostanoid, whereas the 1-series (PGE ) and the 3-series (PGE ) are considered to act as anti-cancer prostanoids. In the present study, we provide possible reasons why PGE and PGE , but not PGE , exert anti-cancer effects by focusing...
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Veröffentlicht in: | FEBS letters 2017-11, Vol.591 (22), p.3771 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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