PGE 1 and E 3 show lower efficacies than E 2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors

The 2-series of prostaglandin E (PGE ) is regarded as a pro-cancer prostanoid, whereas the 1-series (PGE ) and the 3-series (PGE ) are considered to act as anti-cancer prostanoids. In the present study, we provide possible reasons why PGE and PGE , but not PGE , exert anti-cancer effects by focusing...

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Veröffentlicht in:FEBS letters 2017-11, Vol.591 (22), p.3771
Hauptverfasser: Araki, Yumi, Suganami, Akiko, Endo, Suzu, Masuda, Yuta, Fukushima, Keijo, Regan, John W, Murayama, Toshihiko, Tamura, Yutaka, Fujino, Hiromichi
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Sprache:eng
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