N-Heterocyclic carbene-catalyzed [4+2] annulation of β-methyl enals and cyclic trifluoromethyl ketimines for the asymmetric synthesis of dihydroquinazolinone derivatives
The enantioselective oxidative N-heterocyclic carbene-catalyzed [4+2] annulation reaction of β-methyl enals and cyclic trifluoromethyl ketimines has been developed. A series of biologically interesting dihydroquinazolinone derivatives bearing a trifluoromethyl group and a tetrasubstituted stereocent...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017-10, Vol.53 (82), p.11342-11344 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Liu, Qiang Chen, Xiang-Yu Li, Sun Jafari, Ehsan Raabe, Gerhard Enders, Dieter |
| description | The enantioselective oxidative N-heterocyclic carbene-catalyzed [4+2] annulation reaction of β-methyl enals and cyclic trifluoromethyl ketimines has been developed. A series of biologically interesting dihydroquinazolinone derivatives bearing a trifluoromethyl group and a tetrasubstituted stereocenter are efficiently prepared with very good yields and excellent stereoselectivities.
The enantioselective oxidative N-heterocyclic carbene-catalyzed [4+2] annulation reaction of β-methyl enals and cyclic trifluoromethyl ketimines has been developed. |
| doi_str_mv | 10.1039/c7cc06562k |
| format | Article |
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| issn | 1359-7345 1364-548X |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | N-Heterocyclic carbene-catalyzed [4+2] annulation of β-methyl enals and cyclic trifluoromethyl ketimines for the asymmetric synthesis of dihydroquinazolinone derivatives |
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