Toward Therapy of Human Prion Diseases

Three decades after the discovery of prions as the cause of Creutzfeldt-Jakob disease and other transmissible spongiform encephalopathies, we are still nowhere close to finding an effective therapy. Numerous pharmacological interventions have attempted to target various stages of disease progression...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 2018-01, Vol.58 (1), p.331-351
Hauptverfasser:	Aguzzi, Adriano, Lakkaraju, Asvin K.K, Frontzek, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Drug Delivery Systems - methods Drug Discovery - methods Humans immunotherapy luminescent polythiophene conjugates neurodegeneration prion Prion Diseases - drug therapy Prions - drug effects therapeutics ubiquitin proteasome system
Online-Zugang:	Volltext
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