Human Retinoblastoma Susceptibility Gene: Genomic Organization and Analysis of Heterozygous Intragenic Deletion Mutants

A gene in chromosome region 13q14 has been identified as the human retinoblastoma susceptibility (RB) gene on the basis of altered gene expression found in virtually all retinoblastomas. In order to further characterize the RB gene and its structural alterations, we examined genomic clones of the RB...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-04, Vol.85 (7), p.2210-2214
Hauptverfasser:	Bookstein, Robert, Eva Y.-H. P. Lee, To, Hoang, Young, Lih-Jiuan, Sery, Theodore W., Hayes, Robert C., Friedmann, Theodore, Lee, Wen-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Cell Line Cell lines Chromosome Deletion Complementary DNA Deoxyribonuclease BamHI Disease Susceptibility DNA DNA - genetics DNA probes DNA Restriction Enzymes DNA, Neoplasm - genetics Exons Eye Neoplasms - genetics Fibroblasts - analysis Fundamental and applied biological sciences. Psychology Genes. Genome Genetic Carrier Screening Genomics Humans Molecular and cellular biology Molecular genetics Oncogenes Phosphoproteins - genetics Polymorphism, Restriction Fragment Length Proto-Oncogenes Retinoblastoma Retinoblastoma - genetics Retinoblastoma genes Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
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