Cannabinoid CB 1 Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors

An improved understanding of the endocannabinoid system has provided new avenues of drug discovery and development toward the management of pain and other behavioral maladies. Exogenous cannabinoid type 1 (CB ) receptor agonists such as Δ -tetrahydrocannabinol are increasingly used for their medicin...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-12, Vol.363 (3), p.314
Hauptverfasser:	Leonard, Michael Z, Alapafuja, Shakiru O, Ji, Lipin, Shukla, Vidyanand G, Liu, Yingpeng, Nikas, Spyros P, Makriyannis, Alexandros, Bergman, Jack, Kangas, Brian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - administration & dosage Adamantane - adverse effects Adamantane - analogs & derivatives Adamantane - pharmacology Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Arachidonic Acids - administration & dosage Arachidonic Acids - agonists Arachidonic Acids - antagonists & inhibitors Arachidonic Acids - pharmacology Behavior, Animal - drug effects Cannabinoid Receptor Antagonists - administration & dosage Cannabinoid Receptor Antagonists - adverse effects Cannabinoid Receptor Antagonists - pharmacology Cannabinol - administration & dosage Cannabinol - adverse effects Cannabinol - analogs & derivatives Cannabinol - pharmacology Discrimination Learning - drug effects Dose-Response Relationship, Drug Drug Agonism Drug Antagonism Drugs, Investigational - administration & dosage Drugs, Investigational - adverse effects Drugs, Investigational - pharmacology Endocannabinoids - administration & dosage Endocannabinoids - agonists Endocannabinoids - antagonists & inhibitors Endocannabinoids - pharmacology Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacology Glycerides - administration & dosage Glycerides - agonists Glycerides - antagonists & inhibitors Glycerides - pharmacology Injections, Intramuscular Injections, Intravenous Ligands Male Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - metabolism Nerve Tissue Proteins - agonists Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Polyunsaturated Alkamides Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Saimiri
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