P2Y 12 antibody inhibits platelet activity and protects against thrombogenesis

Given that platelet hyperactivity is known to give rise to thrombotic disorders, new and/or novel antiplatelet therapies are constantly being developed to add to, or to complement the current arsenal of agents. To this end, adenosine diphosphate (ADP) is an important platelet activator that acts by...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-11, Vol.493 (2), p.1069
Hauptverfasser:	Hensch, Nicole R, Karim, Zubair A, Pineda, Joshua, Mercado, Nicole, Alshbool, Fatima Z, Khasawneh, Fadi T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Antibodies - therapeutic use Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - metabolism Hemostasis - drug effects Humans Integrins - metabolism Mice, Inbred C57BL Platelet Activation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Purinergic P2Y Receptor Antagonists - pharmacology Purinergic P2Y Receptor Antagonists - therapeutic use Receptors, Purinergic P2Y12 - metabolism Thrombosis - metabolism Thrombosis - prevention & control
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