Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study
OBJECTIVE:We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth. METHODS:Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutritio...
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| creator | Lima, Aldo A.M Soares, Alberto M Filho, José Q.S Havt, Alexandre Lima, Ila F.N Lima, Noélia L Abreu, Cláudia B Junior, Francisco S Mota, Rosa M.S Pan, William K.-.Y Troeger, Christopher Medeiros, Pedro H.Q.S Vera, Herlice N Prata, Mara M.G McCormick, Ben McGrath, Monica Rogawski, Elizabeth Houpt, Eric Platts-Mills, James Gratz, Jean Samie, Amidou Bessong, Pascal Babji, Sudhir Kang, Gangadeep Shahida, Qureshi Shakoor, Sadia Bhutta, Zulfiqar Haque, Rashidul Ahmed, Tahmeed Mduma, Estomih Svensen, Erling Kosek, Margaret Penataro_Yori, Pablo Bodhidatta, Ladaporn Jasmin, Shrestha Mason, Carl Lang, Dennis Gottlieb, Michael Guerrant, Richard L |
| description | OBJECTIVE:We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth.
METHODS:Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life.
RESULTS:Children with subclinical EAEC infection did not show altered growth between enrollment and six months. Conversely, EAEC co-infection with any other pathogen was negatively associated with delta weight-for-length (WLZ) (p 0.05) z-scores between 0 and 6 months. The presence of two or more pathogens without EAEC was not significantly associated with delta WLZ and WAZ. The most frequent EAEC co-infections included Campylobacter spp. heat-labile toxin-producing enterotoxigenic E. coli, Cryptosporidium spp., and atypical enteropathogenic E. coli. Myeloperoxidase levels were increased with EAEC co-infection (p |
| doi_str_mv | 10.1097/MPG.0000000000001717 |
| format | Article |
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METHODS:Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life.
RESULTS:Children with subclinical EAEC infection did not show altered growth between enrollment and six months. Conversely, EAEC co-infection with any other pathogen was negatively associated with delta weight-for-length (WLZ) (p < 0.05) and weight-for-age (WAZ) (p > 0.05) z-scores between 0 and 6 months. The presence of two or more pathogens without EAEC was not significantly associated with delta WLZ and WAZ. The most frequent EAEC co-infections included Campylobacter spp. heat-labile toxin-producing enterotoxigenic E. coli, Cryptosporidium spp., and atypical enteropathogenic E. coli. Myeloperoxidase levels were increased with EAEC co-infection (p < 0.05). EAEC pathogen co-detection was associated with lower neopterin levels compared to those of no-pathogen control children (p < 0.05). Mothers of children with EAEC co-infections had lower levels of education, poorer hygiene and sanitation, lower socioeconomic status, and lower breastfeeding rates compared to mothers of children in whom no pathogen was detected (p < 0.05).
CONCLUSIONS:These data emphasize the public health importance of subclinical EAEC infection in early infancy in association with other pathogens and the need for improved maternal and child care, hygiene, sanitation, and socioeconomic factors.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0000000000001717</identifier><identifier>PMID: 28906319</identifier><language>eng</language><publisher>United States: by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</publisher><ispartof>Journal of pediatric gastroenterology and nutrition, 2017-09</ispartof><rights>2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28906319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Aldo A.M</creatorcontrib><creatorcontrib>Soares, Alberto M</creatorcontrib><creatorcontrib>Filho, José Q.S</creatorcontrib><creatorcontrib>Havt, Alexandre</creatorcontrib><creatorcontrib>Lima, Ila F.N</creatorcontrib><creatorcontrib>Lima, Noélia L</creatorcontrib><creatorcontrib>Abreu, Cláudia B</creatorcontrib><creatorcontrib>Junior, Francisco S</creatorcontrib><creatorcontrib>Mota, Rosa M.S</creatorcontrib><creatorcontrib>Pan, William K.-.Y</creatorcontrib><creatorcontrib>Troeger, Christopher</creatorcontrib><creatorcontrib>Medeiros, Pedro H.Q.S</creatorcontrib><creatorcontrib>Vera, Herlice N</creatorcontrib><creatorcontrib>Prata, Mara M.G</creatorcontrib><creatorcontrib>McCormick, Ben</creatorcontrib><creatorcontrib>McGrath, Monica</creatorcontrib><creatorcontrib>Rogawski, Elizabeth</creatorcontrib><creatorcontrib>Houpt, Eric</creatorcontrib><creatorcontrib>Platts-Mills, James</creatorcontrib><creatorcontrib>Gratz, Jean</creatorcontrib><creatorcontrib>Samie, Amidou</creatorcontrib><creatorcontrib>Bessong, Pascal</creatorcontrib><creatorcontrib>Babji, Sudhir</creatorcontrib><creatorcontrib>Kang, Gangadeep</creatorcontrib><creatorcontrib>Shahida, Qureshi</creatorcontrib><creatorcontrib>Shakoor, Sadia</creatorcontrib><creatorcontrib>Bhutta, Zulfiqar</creatorcontrib><creatorcontrib>Haque, Rashidul</creatorcontrib><creatorcontrib>Ahmed, Tahmeed</creatorcontrib><creatorcontrib>Mduma, Estomih</creatorcontrib><creatorcontrib>Svensen, Erling</creatorcontrib><creatorcontrib>Kosek, Margaret</creatorcontrib><creatorcontrib>Penataro_Yori, Pablo</creatorcontrib><creatorcontrib>Bodhidatta, Ladaporn</creatorcontrib><creatorcontrib>Jasmin, Shrestha</creatorcontrib><creatorcontrib>Mason, Carl</creatorcontrib><creatorcontrib>Lang, Dennis</creatorcontrib><creatorcontrib>Gottlieb, Michael</creatorcontrib><creatorcontrib>Guerrant, Richard L</creatorcontrib><title>Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>OBJECTIVE:We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth.
METHODS:Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life.
RESULTS:Children with subclinical EAEC infection did not show altered growth between enrollment and six months. Conversely, EAEC co-infection with any other pathogen was negatively associated with delta weight-for-length (WLZ) (p < 0.05) and weight-for-age (WAZ) (p > 0.05) z-scores between 0 and 6 months. The presence of two or more pathogens without EAEC was not significantly associated with delta WLZ and WAZ. The most frequent EAEC co-infections included Campylobacter spp. heat-labile toxin-producing enterotoxigenic E. coli, Cryptosporidium spp., and atypical enteropathogenic E. coli. Myeloperoxidase levels were increased with EAEC co-infection (p < 0.05). EAEC pathogen co-detection was associated with lower neopterin levels compared to those of no-pathogen control children (p < 0.05). Mothers of children with EAEC co-infections had lower levels of education, poorer hygiene and sanitation, lower socioeconomic status, and lower breastfeeding rates compared to mothers of children in whom no pathogen was detected (p < 0.05).
CONCLUSIONS:These data emphasize the public health importance of subclinical EAEC infection in early infancy in association with other pathogens and the need for improved maternal and child care, hygiene, sanitation, and socioeconomic factors.</description><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkNFKwzAUhoMobk7fQCQv0Jk0bZJeSq1zsKGw3Ze0SdZo1pY0XdnbW52KeG4O_P_HgfMBcIvRHKOE3a9fF3P0ZzDD7AxMcUxoEHGEz8EUhYwFIcZ0Aq667m2EWBSjSzAJeYIowckUHLLaK9eI3c6pnfDmoGA2h2VjDdz0RWlNbUph4bLWqvSmqaGo5VgHv0H3lSz3rTBOSZhWxkq4cM3gK2hq6CsF1w-rIHuEaVM1zsON7-XxGlxoYTt1871nYPuUbdPnYPWyWKYj37KQBbKMuIoTxEUZa4JUojlNYoQKWmjCMCeKh0RQOlZYS02iWMiCCc2IjHQhYzIDd6ezbV_slcxbZ_bCHfOf_0eAn4ChsaOH7t32g3J5pYT1VY5R_qk6H1Xn_1WTD48pb1E</recordid><startdate>20170912</startdate><enddate>20170912</enddate><creator>Lima, Aldo A.M</creator><creator>Soares, Alberto M</creator><creator>Filho, José Q.S</creator><creator>Havt, Alexandre</creator><creator>Lima, Ila F.N</creator><creator>Lima, Noélia L</creator><creator>Abreu, Cláudia B</creator><creator>Junior, Francisco S</creator><creator>Mota, Rosa M.S</creator><creator>Pan, William K.-.Y</creator><creator>Troeger, Christopher</creator><creator>Medeiros, Pedro H.Q.S</creator><creator>Vera, Herlice N</creator><creator>Prata, Mara M.G</creator><creator>McCormick, Ben</creator><creator>McGrath, Monica</creator><creator>Rogawski, Elizabeth</creator><creator>Houpt, Eric</creator><creator>Platts-Mills, James</creator><creator>Gratz, Jean</creator><creator>Samie, Amidou</creator><creator>Bessong, Pascal</creator><creator>Babji, Sudhir</creator><creator>Kang, Gangadeep</creator><creator>Shahida, Qureshi</creator><creator>Shakoor, Sadia</creator><creator>Bhutta, Zulfiqar</creator><creator>Haque, Rashidul</creator><creator>Ahmed, Tahmeed</creator><creator>Mduma, Estomih</creator><creator>Svensen, Erling</creator><creator>Kosek, Margaret</creator><creator>Penataro_Yori, Pablo</creator><creator>Bodhidatta, Ladaporn</creator><creator>Jasmin, Shrestha</creator><creator>Mason, Carl</creator><creator>Lang, Dennis</creator><creator>Gottlieb, Michael</creator><creator>Guerrant, Richard L</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><scope>NPM</scope></search><sort><creationdate>20170912</creationdate><title>Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study</title><author>Lima, Aldo A.M ; Soares, Alberto M ; Filho, José Q.S ; Havt, Alexandre ; Lima, Ila F.N ; Lima, Noélia L ; Abreu, Cláudia B ; Junior, Francisco S ; Mota, Rosa M.S ; Pan, William K.-.Y ; Troeger, Christopher ; Medeiros, Pedro H.Q.S ; Vera, Herlice N ; Prata, Mara M.G ; McCormick, Ben ; McGrath, Monica ; Rogawski, Elizabeth ; Houpt, Eric ; Platts-Mills, James ; Gratz, Jean ; Samie, Amidou ; Bessong, Pascal ; Babji, Sudhir ; Kang, Gangadeep ; Shahida, Qureshi ; Shakoor, Sadia ; Bhutta, Zulfiqar ; Haque, Rashidul ; Ahmed, Tahmeed ; Mduma, Estomih ; Svensen, Erling ; Kosek, Margaret ; Penataro_Yori, Pablo ; Bodhidatta, Ladaporn ; Jasmin, Shrestha ; Mason, Carl ; Lang, Dennis ; Gottlieb, Michael ; Guerrant, Richard L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p727-dc48e5908ac5f30e9f869500b6bf37183e823a6630e1fdf345adb7af73d4fbd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Aldo A.M</creatorcontrib><creatorcontrib>Soares, Alberto M</creatorcontrib><creatorcontrib>Filho, José Q.S</creatorcontrib><creatorcontrib>Havt, Alexandre</creatorcontrib><creatorcontrib>Lima, Ila F.N</creatorcontrib><creatorcontrib>Lima, Noélia L</creatorcontrib><creatorcontrib>Abreu, Cláudia B</creatorcontrib><creatorcontrib>Junior, Francisco S</creatorcontrib><creatorcontrib>Mota, Rosa M.S</creatorcontrib><creatorcontrib>Pan, William K.-.Y</creatorcontrib><creatorcontrib>Troeger, Christopher</creatorcontrib><creatorcontrib>Medeiros, Pedro H.Q.S</creatorcontrib><creatorcontrib>Vera, Herlice N</creatorcontrib><creatorcontrib>Prata, Mara M.G</creatorcontrib><creatorcontrib>McCormick, Ben</creatorcontrib><creatorcontrib>McGrath, Monica</creatorcontrib><creatorcontrib>Rogawski, Elizabeth</creatorcontrib><creatorcontrib>Houpt, Eric</creatorcontrib><creatorcontrib>Platts-Mills, James</creatorcontrib><creatorcontrib>Gratz, Jean</creatorcontrib><creatorcontrib>Samie, Amidou</creatorcontrib><creatorcontrib>Bessong, Pascal</creatorcontrib><creatorcontrib>Babji, Sudhir</creatorcontrib><creatorcontrib>Kang, Gangadeep</creatorcontrib><creatorcontrib>Shahida, Qureshi</creatorcontrib><creatorcontrib>Shakoor, Sadia</creatorcontrib><creatorcontrib>Bhutta, Zulfiqar</creatorcontrib><creatorcontrib>Haque, Rashidul</creatorcontrib><creatorcontrib>Ahmed, Tahmeed</creatorcontrib><creatorcontrib>Mduma, Estomih</creatorcontrib><creatorcontrib>Svensen, Erling</creatorcontrib><creatorcontrib>Kosek, Margaret</creatorcontrib><creatorcontrib>Penataro_Yori, Pablo</creatorcontrib><creatorcontrib>Bodhidatta, Ladaporn</creatorcontrib><creatorcontrib>Jasmin, Shrestha</creatorcontrib><creatorcontrib>Mason, Carl</creatorcontrib><creatorcontrib>Lang, Dennis</creatorcontrib><creatorcontrib>Gottlieb, Michael</creatorcontrib><creatorcontrib>Guerrant, Richard L</creatorcontrib><collection>PubMed</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Aldo A.M</au><au>Soares, Alberto M</au><au>Filho, José Q.S</au><au>Havt, Alexandre</au><au>Lima, Ila F.N</au><au>Lima, Noélia L</au><au>Abreu, Cláudia B</au><au>Junior, Francisco S</au><au>Mota, Rosa M.S</au><au>Pan, William K.-.Y</au><au>Troeger, Christopher</au><au>Medeiros, Pedro H.Q.S</au><au>Vera, Herlice N</au><au>Prata, Mara M.G</au><au>McCormick, Ben</au><au>McGrath, Monica</au><au>Rogawski, Elizabeth</au><au>Houpt, Eric</au><au>Platts-Mills, James</au><au>Gratz, Jean</au><au>Samie, Amidou</au><au>Bessong, Pascal</au><au>Babji, Sudhir</au><au>Kang, Gangadeep</au><au>Shahida, Qureshi</au><au>Shakoor, Sadia</au><au>Bhutta, Zulfiqar</au><au>Haque, Rashidul</au><au>Ahmed, Tahmeed</au><au>Mduma, Estomih</au><au>Svensen, Erling</au><au>Kosek, Margaret</au><au>Penataro_Yori, Pablo</au><au>Bodhidatta, Ladaporn</au><au>Jasmin, Shrestha</au><au>Mason, Carl</au><au>Lang, Dennis</au><au>Gottlieb, Michael</au><au>Guerrant, Richard L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2017-09-12</date><risdate>2017</risdate><issn>0277-2116</issn><eissn>1536-4801</eissn><abstract>OBJECTIVE:We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth.
METHODS:Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life.
RESULTS:Children with subclinical EAEC infection did not show altered growth between enrollment and six months. Conversely, EAEC co-infection with any other pathogen was negatively associated with delta weight-for-length (WLZ) (p < 0.05) and weight-for-age (WAZ) (p > 0.05) z-scores between 0 and 6 months. The presence of two or more pathogens without EAEC was not significantly associated with delta WLZ and WAZ. The most frequent EAEC co-infections included Campylobacter spp. heat-labile toxin-producing enterotoxigenic E. coli, Cryptosporidium spp., and atypical enteropathogenic E. coli. Myeloperoxidase levels were increased with EAEC co-infection (p < 0.05). EAEC pathogen co-detection was associated with lower neopterin levels compared to those of no-pathogen control children (p < 0.05). Mothers of children with EAEC co-infections had lower levels of education, poorer hygiene and sanitation, lower socioeconomic status, and lower breastfeeding rates compared to mothers of children in whom no pathogen was detected (p < 0.05).
CONCLUSIONS:These data emphasize the public health importance of subclinical EAEC infection in early infancy in association with other pathogens and the need for improved maternal and child care, hygiene, sanitation, and socioeconomic factors.</abstract><cop>United States</cop><pub>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</pub><pmid>28906319</pmid><doi>10.1097/MPG.0000000000001717</doi></addata></record> |
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| source | Journals@Ovid Ovid Autoload; Wiley Online Library All Journals |
| title | Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study |
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