Defining the Architecture of the Core Machinery for the Assembly of Fe-S Clusters in Human Mitochondria

Although Fe-S clusters may assemble spontaneously from elemental iron and sulfur in protein-free systems, the potential toxicity of free Fe , Fe , and S ions in aerobic environments underscores the requirement for specialized proteins to oversee the safe assembly of Fe-S clusters in living cells. Pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Methods in enzymology 2017, Vol.595, p.107
Hauptverfasser:	Gakh, Oleksandr, Ranatunga, Wasantha, Galeano, Belinda K, Smith, 4th, Douglas S, Thompson, James R, Isaya, Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon-Sulfur Lyases - chemistry Carbon-Sulfur Lyases - metabolism Escherichia coli - metabolism Frataxin Humans Iron - chemistry Iron - toxicity Iron-Binding Proteins - chemistry Iron-Binding Proteins - metabolism Iron-Regulatory Proteins - chemistry Iron-Regulatory Proteins - metabolism Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - metabolism Mitochondria - metabolism Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Models, Molecular Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sulfur - chemistry Sulfur - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!