1 H, 15 N and 13 C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase

1 H, 15 N and 13 C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase

The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [ C, N]-labeled protein. These assignments facilitate further studies of HePTP in the presence of...

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Veröffentlicht in:Biomolecular NMR assignments 2018-04, Vol.12 (1), p.5
Hauptverfasser: Machado, Luciana E S F, Page, Rebecca, Peti, Wolfgang
Format: Artikel
Sprache:eng
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Zusammenfassung:The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [ C, N]-labeled protein. These assignments facilitate further studies of HePTP in the presence of inhibitors to target leukemia and provide further insights into the function of protein tyrosine phosphatases.
ISSN:1874-270X
DOI:10.1007/s12104-017-9770-7