Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT 2C Modulators

A series of pyrimidine derivatives - were synthesized and evaluated for their binding affinities towards 5-HT receptors. With regard to designed molecules - , the influence of the size of alkyl ether and the absolute configuration of a stereogenic center on the 5-HT binding affinity and selectivity...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-08, Vol.22 (9)
Hauptverfasser:	Kim, Juhyeon, Jo, Hanbyeol, Lee, Hyunseung, Choo, Hyunah, Kim, Hak Joong, Pae, Ae Nim, Cho, Yong Seo, Min, Sun-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cricetulus Models, Molecular Molecular Structure Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Receptor, Serotonin, 5-HT2C - metabolism Serotonin 5-HT2 Receptor Agonists - chemical synthesis Serotonin 5-HT2 Receptor Agonists - chemistry Serotonin 5-HT2 Receptor Agonists - pharmacology Structure-Activity Relationship
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