P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes

Background: TGFβ1, a decisive regulator of megakaryocyte maturation and platelet formation, has previously been shown to up-regulate both, store operated Ca 2+ entry (SOCE) and Ca 2+ extrusion by Na + /Ca 2+ exchange. The growth factor thus augments the increase of cytosolic Ca 2+ activity ([Ca 2+ ]...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017, Vol.42 (6), p.2169-2181
Hauptverfasser:	Al-Maghout, Tamer, Pelzl, Lisann, Sahu, Itishri, Sukkar, Basma, Hosseinzadeh, Zohreh, Gutti, Ravi, Laufer, Stefan, Voelkl, Jakob, Pieske, Burkert, Gawaz, Meinrad, Lang, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoates - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Calcium Calcium - metabolism Cell Line Dibenzocycloheptenes - pharmacology Flavanones - pharmacology Humans Immediate-Early Proteins - antagonists & inhibitors Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - metabolism Microscopy, Fluorescence NCKX1 NCKX2 NCKX5 NCX1 NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB Original Paper p38 kinase p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction SGK1 Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism Transcription, Genetic - drug effects Transforming Growth Factor beta1 - pharmacology Up-Regulation - drug effects
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