Mettl3-mediated m 6 A regulates spermatogonial differentiation and meiosis initiation

METTL3 catalyzes the formation of N -methyl-adenosine (m A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was ess...

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Veröffentlicht in:	Cell research 2017-09, Vol.27 (9), p.1100
Hauptverfasser:	Xu, Kai, Yang, Ying, Feng, Gui-Hai, Sun, Bao-Fa, Chen, Jun-Qing, Li, Yu-Fei, Chen, Yu-Sheng, Zhang, Xin-Xin, Wang, Chen-Xin, Jiang, Li-Yuan, Liu, Chao, Zhang, Ze-Yu, Wang, Xiu-Jie, Zhou, Qi, Yang, Yun-Gui, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Alternative Splicing - genetics Animals Base Sequence Cell Differentiation - genetics Fertility Gene Deletion Gene Expression Regulation, Developmental Male Meiosis - genetics Methyltransferases - genetics Methyltransferases - metabolism Mice, Inbred C57BL Spermatogenesis - genetics Spermatogonia - cytology Spermatogonia - metabolism
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