Nerves, H 2 O 2 and Shh: Three players in the game of regeneration
The tight control of reactive oxygen species (ROS) levels is required during regeneration. H O in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H O through the activation of the Hedgehog (Shh) pathway, providing an environment...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2018-08, Vol.80, p.65 |
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| container_title | Seminars in cell & developmental biology |
| container_volume | 80 |
| creator | Meda, Francesca Rampon, Christine Dupont, Edmond Gauron, Carole Mourton, Aurélien Queguiner, Isabelle Thauvin, Marion Volovitch, Michel Joliot, Alain Vriz, Sophie |
| description | The tight control of reactive oxygen species (ROS) levels is required during regeneration. H
O
in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H
O
through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H
O
levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H
O
levels to their original state. A similar regulatory loop between H
O
levels and nerves also exists during development. This suggests that redox signalling is a major actor in cell plasticity. |
| format | Article |
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O
in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H
O
through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H
O
levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H
O
levels to their original state. A similar regulatory loop between H
O
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O
in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H
O
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O
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O
levels to their original state. A similar regulatory loop between H
O
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O
in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H
O
through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H
O
levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H
O
levels to their original state. A similar regulatory loop between H
O
levels and nerves also exists during development. This suggests that redox signalling is a major actor in cell plasticity.</abstract><cop>England</cop><pmid>28797840</pmid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1096-3634 |
| ispartof | Seminars in cell & developmental biology, 2018-08, Vol.80, p.65 |
| issn | 1096-3634 |
| language | eng |
| recordid | cdi_pubmed_primary_28797840 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Hedgehog Proteins - metabolism Humans Hydrogen Peroxide - metabolism Nerve Net - metabolism Reactive Oxygen Species - metabolism Regeneration - physiology Signal Transduction - physiology |
| title | Nerves, H 2 O 2 and Shh: Three players in the game of regeneration |
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