Vesicle Docking Is a Key Target of Local PI(4,5)P 2 Metabolism in the Secretory Pathway of INS-1 Cells

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P ) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to control PI(4,5)P levels in time and space in...

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Veröffentlicht in:	Cell reports (Cambridge) 2017-08, Vol.20 (6), p.1409
Hauptverfasser:	Ji, Chen, Fan, Fan, Lou, Xuelin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Signaling Cell Line Cell Membrane - metabolism Insulin - metabolism Insulin-Secreting Cells - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Rats Secretory Pathway Secretory Vesicles - metabolism Syntaxin 1 - metabolism
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