Zika virus replication in the mosquito Culex quinquefasciatus in Brazil
Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mos...
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| creator | Guedes, Duschinka RD Paiva, Marcelo HS Donato, Mariana MA Barbosa, Priscilla P Krokovsky, Larissa Rocha, Sura W dos S Saraiva, Karina LA Crespo, Mônica M Rezende, Tatiana MT Wallau, Gabriel L Barbosa, Rosângela MR Oliveira, Cláudia MF Melo-Santos, Maria AV Pena, Lindomar Cordeiro, Marli T Franca, Rafael F de O Oliveira, André LS de Peixoto, Christina A Leal, Walter S Ayres, Constância FJ |
| description | Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide; however, there is evidence that other mosquito species, including Culex quinquefasciatus, transmit the virus. To test the potential of Cx. quinquefasciatus to transmit ZIKV, we experimentally compared the vector competence of laboratory-reared Ae. aegypti and Cx. quinquefasciatus. Interestingly, we were able to detect the presence of ZIKV in the midgut, salivary glands and saliva of artificially fed Cx. quinquefasciatus. In addition, we collected ZIKV-infected Cx. quinquefasciatus from urban areas with high microcephaly incidence in Recife, Brazil. Corroborating our experimental data from artificially fed mosquitoes, ZIKV was isolated from field-caught Cx. quinquefasciatus, and its genome was partially sequenced. Collectively, these findings indicate that there may be a wider range of ZIKV vectors than anticipated.
Emerging Microbes & Infections (2017) 6, e69; doi:10.1038/emi.2017.59; published online 9 August 2017 |
| doi_str_mv | 10.1038/emi.2017.59 |
| format | Article |
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Emerging Microbes & Infections (2017) 6, e69; doi:10.1038/emi.2017.59; published online 9 August 2017</description><identifier>ISSN: 2222-1751</identifier><identifier>EISSN: 2222-1751</identifier><identifier>DOI: 10.1038/emi.2017.59</identifier><identifier>PMID: 28790458</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Aedes ; Aedes - virology ; Animals ; Brazil - epidemiology ; Culex ; Culex - virology ; Genome, Viral ; Humans ; Microcephaly ; Microcephaly - epidemiology ; Mosquito Vectors - physiology ; Mosquito Vectors - virology ; Mosquitoes ; Original ; Saliva - virology ; Salivary Glands - virology ; Sequence Analysis, DNA ; vector competence ; Virus Replication ; Zika ; Zika virus ; Zika Virus - genetics ; Zika Virus - isolation & purification ; Zika Virus - physiology ; Zika Virus Infection - epidemiology ; Zika Virus Infection - transmission ; Zika Virus Infection - virology</subject><ispartof>Emerging microbes & infections, 2017-08, Vol.6 (1), p.1-11</ispartof><rights>The Author(s) 2017 2017</rights><rights>The Author(s) 2017. This work is licensed under the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-8c56707a7e892de98740e08a06bc920cdf5d1fa348fc97653c6f0bb64780ea2d3</citedby><cites>FETCH-LOGICAL-c522t-8c56707a7e892de98740e08a06bc920cdf5d1fa348fc97653c6f0bb64780ea2d3</cites><orcidid>0000-0003-1134-5699 ; 0000-0002-1419-5713</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,27483,27905,27906,53772,53774,59122,59123</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28790458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guedes, Duschinka RD</creatorcontrib><creatorcontrib>Paiva, Marcelo HS</creatorcontrib><creatorcontrib>Donato, Mariana MA</creatorcontrib><creatorcontrib>Barbosa, Priscilla P</creatorcontrib><creatorcontrib>Krokovsky, Larissa</creatorcontrib><creatorcontrib>Rocha, Sura W dos S</creatorcontrib><creatorcontrib>Saraiva, Karina LA</creatorcontrib><creatorcontrib>Crespo, Mônica M</creatorcontrib><creatorcontrib>Rezende, Tatiana MT</creatorcontrib><creatorcontrib>Wallau, Gabriel L</creatorcontrib><creatorcontrib>Barbosa, Rosângela MR</creatorcontrib><creatorcontrib>Oliveira, Cláudia MF</creatorcontrib><creatorcontrib>Melo-Santos, Maria AV</creatorcontrib><creatorcontrib>Pena, Lindomar</creatorcontrib><creatorcontrib>Cordeiro, Marli T</creatorcontrib><creatorcontrib>Franca, Rafael F de O</creatorcontrib><creatorcontrib>Oliveira, André LS de</creatorcontrib><creatorcontrib>Peixoto, Christina A</creatorcontrib><creatorcontrib>Leal, Walter S</creatorcontrib><creatorcontrib>Ayres, Constância FJ</creatorcontrib><title>Zika virus replication in the mosquito Culex quinquefasciatus in Brazil</title><title>Emerging microbes & infections</title><addtitle>Emerg Microbes Infect</addtitle><description>Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide; however, there is evidence that other mosquito species, including Culex quinquefasciatus, transmit the virus. To test the potential of Cx. quinquefasciatus to transmit ZIKV, we experimentally compared the vector competence of laboratory-reared Ae. aegypti and Cx. quinquefasciatus. Interestingly, we were able to detect the presence of ZIKV in the midgut, salivary glands and saliva of artificially fed Cx. quinquefasciatus. In addition, we collected ZIKV-infected Cx. quinquefasciatus from urban areas with high microcephaly incidence in Recife, Brazil. Corroborating our experimental data from artificially fed mosquitoes, ZIKV was isolated from field-caught Cx. quinquefasciatus, and its genome was partially sequenced. Collectively, these findings indicate that there may be a wider range of ZIKV vectors than anticipated.
Emerging Microbes & Infections (2017) 6, e69; doi:10.1038/emi.2017.59; published online 9 August 2017</description><subject>Aedes</subject><subject>Aedes - virology</subject><subject>Animals</subject><subject>Brazil - epidemiology</subject><subject>Culex</subject><subject>Culex - virology</subject><subject>Genome, Viral</subject><subject>Humans</subject><subject>Microcephaly</subject><subject>Microcephaly - epidemiology</subject><subject>Mosquito Vectors - physiology</subject><subject>Mosquito Vectors - virology</subject><subject>Mosquitoes</subject><subject>Original</subject><subject>Saliva - virology</subject><subject>Salivary Glands - virology</subject><subject>Sequence Analysis, DNA</subject><subject>vector competence</subject><subject>Virus Replication</subject><subject>Zika</subject><subject>Zika virus</subject><subject>Zika Virus - genetics</subject><subject>Zika Virus - isolation & purification</subject><subject>Zika Virus - physiology</subject><subject>Zika Virus Infection - epidemiology</subject><subject>Zika Virus Infection - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Emerging microbes & infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guedes, Duschinka RD</au><au>Paiva, Marcelo HS</au><au>Donato, Mariana MA</au><au>Barbosa, Priscilla P</au><au>Krokovsky, Larissa</au><au>Rocha, Sura W dos S</au><au>Saraiva, Karina LA</au><au>Crespo, Mônica M</au><au>Rezende, Tatiana MT</au><au>Wallau, Gabriel L</au><au>Barbosa, Rosângela MR</au><au>Oliveira, Cláudia MF</au><au>Melo-Santos, Maria AV</au><au>Pena, Lindomar</au><au>Cordeiro, Marli T</au><au>Franca, Rafael F de O</au><au>Oliveira, André LS de</au><au>Peixoto, Christina A</au><au>Leal, Walter S</au><au>Ayres, Constância FJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zika virus replication in the mosquito Culex quinquefasciatus in Brazil</atitle><jtitle>Emerging microbes & infections</jtitle><addtitle>Emerg Microbes Infect</addtitle><date>2017-08-09</date><risdate>2017</risdate><volume>6</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2222-1751</issn><eissn>2222-1751</eissn><abstract>Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide; however, there is evidence that other mosquito species, including Culex quinquefasciatus, transmit the virus. To test the potential of Cx. quinquefasciatus to transmit ZIKV, we experimentally compared the vector competence of laboratory-reared Ae. aegypti and Cx. quinquefasciatus. Interestingly, we were able to detect the presence of ZIKV in the midgut, salivary glands and saliva of artificially fed Cx. quinquefasciatus. In addition, we collected ZIKV-infected Cx. quinquefasciatus from urban areas with high microcephaly incidence in Recife, Brazil. Corroborating our experimental data from artificially fed mosquitoes, ZIKV was isolated from field-caught Cx. quinquefasciatus, and its genome was partially sequenced. Collectively, these findings indicate that there may be a wider range of ZIKV vectors than anticipated.
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| subjects | Aedes Aedes - virology Animals Brazil - epidemiology Culex Culex - virology Genome, Viral Humans Microcephaly Microcephaly - epidemiology Mosquito Vectors - physiology Mosquito Vectors - virology Mosquitoes Original Saliva - virology Salivary Glands - virology Sequence Analysis, DNA vector competence Virus Replication Zika Zika virus Zika Virus - genetics Zika Virus - isolation & purification Zika Virus - physiology Zika Virus Infection - epidemiology Zika Virus Infection - transmission Zika Virus Infection - virology |
| title | Zika virus replication in the mosquito Culex quinquefasciatus in Brazil |
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