Molecular Events in the Natural History of Pancreatic Cancer

Molecular Events in the Natural History of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural...

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Veröffentlicht in:Trends in Cancer 2017-05, Vol.3 (5), p.336-346
Hauptverfasser: Oldfield, Leslie E, Connor, Ashton A, Gallinger, Steven
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Sprache:eng
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Disease Progression
Humans
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
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creator Oldfield, Leslie E
Connor, Ashton A
Gallinger, Steven
description Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural history of PDAC, including its cell of origin, the initiating somatic mutational events, pathways deranged in the mature tumor, its biological heterogeneity, and the relationship of the primary tumor with metastases. We also suggest areas for further research and highlight translatable findings that are beginning to make clinical inroads.
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subjects Disease Progression
Humans
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
title Molecular Events in the Natural History of Pancreatic Cancer
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