Pentanoic acid induces thymic stromal lymphopoietin production through G q/11 and Rho-associated protein kinase signaling pathway in keratinocytes

Thymic stromal lymphopoietin (TSLP) plays an important role in allergic skin inflammation. Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear....

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Veröffentlicht in:	International immunopharmacology 2017-09, Vol.50, p.216
Hauptverfasser:	Mizuno, Natsumi, Abe, Koudai, Morishita, Yukari, Yamashita, Saori, Segawa, Ryosuke, Dong, Jiangxu, Moriya, Takahiro, Hiratsuka, Masahiro, Hirasawa, Noriyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Cells, Cultured Cytokines - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Humans Hypersensitivity - immunology Keratinocytes - drug effects Keratinocytes - physiology Mice Mice, Inbred BALB C Pentanoic Acids - immunology Pentanoic Acids - metabolism Peptides, Cyclic - pharmacology Pyridines - pharmacology rho-Associated Kinases - metabolism RNA, Small Interfering - genetics Signal Transduction Skin - immunology Skin - pathology
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