Transcriptomic Perspectives on Neocortical Structure, Development, Evolution, and Disease
The cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances ha...
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| Veröffentlicht in: | Annual review of neuroscience 2017-07, Vol.40 (1), p.629-652 |
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| creator | Lein, Ed S Belgard, T. Grant Hawrylycz, Michael Molnár, Zoltán |
| description | The cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances have propelled this field to the high-throughput study of the complete set of transcribed genes at increasingly fine resolution to the level of individual cells. These tools have revealed features of the genetic architecture of adult cortical areas, layers, and cell types, as well as spatiotemporal patterning during development. This has allowed a fresh look at comparative anatomy as well, illustrating surprisingly large differences between mammals while at the same time revealing conservation of some features from avians to mammals. Finally, transcriptomics is fueling progress in understanding the causes of neurodevelopmental diseases such as autism, linking genetic association studies to specific molecular pathways and affected brain regions. |
| doi_str_mv | 10.1146/annurev-neuro-070815-013858 |
| format | Article |
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This has allowed a fresh look at comparative anatomy as well, illustrating surprisingly large differences between mammals while at the same time revealing conservation of some features from avians to mammals. 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Grant</creatorcontrib><creatorcontrib>Hawrylycz, Michael</creatorcontrib><creatorcontrib>Molnár, Zoltán</creatorcontrib><title>Transcriptomic Perspectives on Neocortical Structure, Development, Evolution, and Disease</title><title>Annual review of neuroscience</title><addtitle>Annu Rev Neurosci</addtitle><description>The cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances have propelled this field to the high-throughput study of the complete set of transcribed genes at increasingly fine resolution to the level of individual cells. These tools have revealed features of the genetic architecture of adult cortical areas, layers, and cell types, as well as spatiotemporal patterning during development. 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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Anatomy Animals Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - pathology Biological Evolution Brain Cerebral cortex Cerebral Cortex - pathology Cerebral Cortex - physiopathology chick Cognitive ability Disease Evolution Genes Genetic Association Studies Genetic code High-throughput screening human Humans Mammals Mental disorders mouse Neurodevelopmental disorders Neurological diseases nonhuman primate Pattern formation Refueling Species Specificity Transcription factors Transcriptome |
| title | Transcriptomic Perspectives on Neocortical Structure, Development, Evolution, and Disease |
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