Role of P2X 7 R in the development and progression of pulmonary hypertension

Pulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes to PAH pathogenesis, but the role of the upstream molecular P2X receptor (P2X R) has remain...

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Veröffentlicht in:	Respiratory research 2017-06, Vol.18 (1), p.127
Hauptverfasser:	Yin, Jie, You, Shuling, Liu, Haopeng, Chen, Li, Zhang, Chengdong, Hu, Hesheng, Xue, Mei, Cheng, Wenjuan, Wang, Ye, Li, Xinran, Shi, Yugen, Li, Nannan, Yan, Suhua, Li, Xiaolu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Progression Dose-Response Relationship, Drug Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Male Purinergic P2X Receptor Antagonists - pharmacology Rats Rats, Sprague-Dawley Receptors, Purinergic P2X7 - physiology
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