A structural mechanism of flavonoids in inhibiting serine proteases

Quercetin is a member of the flavonoids and was previously demonstrated to inhibit trypsin-like serine proteases at micromolar potencies. Different molecular models were proposed to explain such inhibition. However, controversies remain on the molecular details of inhibition. Here, we report the X-r...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Food & function 2017-07, Vol.8 (7), p.2437-2443
Hauptverfasser:	Xue, Guangpu, Gong, Lihu, Yuan, Cai, Xu, Mingming, Wang, Xu, Jiang, Longguang, Huang, Mingdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Flavonoids - chemistry Humans Kinetics Models, Molecular Protein Binding Protein Conformation Serine Proteinase Inhibitors - chemistry Urokinase-Type Plasminogen Activator - antagonists & inhibitors Urokinase-Type Plasminogen Activator - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!