A chronic low dose of Δ 9 -tetrahydrocannabinol (THC) restores cognitive function in old mice

The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiologi...

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Veröffentlicht in:	Nature medicine 2017-06, Vol.23 (6), p.782
Hauptverfasser:	Bilkei-Gorzo, Andras, Albayram, Onder, Draffehn, Astrid, Michel, Kerstin, Piyanova, Anastasia, Oppenheimer, Hannah, Dvir-Ginzberg, Mona, Rácz, Ildiko, Ulas, Thomas, Imbeault, Sophie, Bab, Itai, Schultze, Joachim L, Zimmer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Aging - metabolism Aging - psychology Animals Behavior, Animal - drug effects Cognition - drug effects Cognitive Aging - psychology Cognitive Dysfunction - metabolism Cognitive Dysfunction - psychology Dendritic Spines - drug effects Dendritic Spines - metabolism Dendritic Spines - pathology Dronabinol - pharmacology Endocannabinoids - metabolism Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Histone Code - drug effects Memory, Long-Term - drug effects Mice Mice, Knockout Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - genetics Spatial Learning - drug effects Spatial Memory - drug effects Transcriptome - drug effects
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