Breast cancer stem-like cells can promote metastasis by activating platelets and down-regulating antitumor activity of natural killer cells

OBJECTIVE:To investigate whether cancer stem cells(CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis.METHODS:We enriched and identified sphereforming cells(SFCs) and coincubated washed platelets with several platelet activators includ...

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Veröffentlicht in:	Journal of traditional Chinese medicine 2016-08, Vol.36 (4), p.530-537
Hauptverfasser:	Wang, Shuo, Zhang, Ying, Cong, Weihong, Liu, Jie, Zhang, Yuren, Fan, Huiting, Xu, Yonggang, Lin, Hongsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Natural Animals Blood Platelets - cytology Blood Platelets - immunology Breast Breast Neoplasms - immunology Breast Neoplasms - pathology cell Cell Line, Tumor cells Metastasis cells natural Female Humans Immune Evasion killer Killer Cells, Natural - immunology metastasis Platelet Mice Mice, Inbred BALB C Neoplasm Neoplasm Metastasis neoplasms Cancer Neoplastic Neoplastic Stem Cells - cytology Neoplastic Stem Cells - immunology stem Thromboplastin - genetics Thromboplastin - immunology
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