The effect of presynchronization with prostaglandin F 2α and gonadotropin-releasing hormone simultaneously, 7 d before Ovsynch, compared with Presynch-10/Ovsynch on luteal function and first-service pregnancies per artificial insemination
Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH...
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| Veröffentlicht in: | Journal of dairy science 2017-06, Vol.100 (6), p.5107 |
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| creator | Martins, J P N Acevedo, M J T Cunha, T O Piterini, C Pursley, J R |
| description | Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH of Ovsynch. The hypothesis of this experiment was that simplification of a presynchronization program through the combination of PGF
and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10. Lactating dairy cows (n = 432) 41 to 47 d in milk (DIM) were randomly assigned to 2 treatments within parities for first service. Control cows received Presynch-10/Ovsynch consisting of the following: PGF
-14 d-PGF
-10 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. Treated cows received PGF
and GnRH-7 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. All cows received a supplemental injection of PGF
24 h after the PGF
of Ovsynch to enhance complete luteolysis. All cows received timed AI between 75 and 81 DIM. Blood was collected to assess circulating concentrations of progesterone (P4), and the number and size of corpora lutea (CL) were recorded using ultrasonography on day of PGF
of Ovsynch. The administration of PGF
simultaneously with GnRH and 7 d before Ovsynch (PG+G) had similar P/AI at 28 (46 vs. 48%), 35 (43 vs. 43%), 49 (39 vs. 39%), and 77 d post-AI (38 vs. 39%) compared with Presynch-10. No differences were observed in P/AI in primiparous versus multiparous cows at 28 (52 vs. 45%), 35 (48 vs. 41%), 49 (45 vs. 37%), and 77 d post-AI (43 vs. 36%). No difference existed between treatments in percentage of cows with functional CL at PGF
of Ovsynch, total luteal area (mm
), or serum concentrations of P4 at time of PGF
of Ovsynch, regardless of parity. Number of CL had a tendency to be greater for multiparous PG+G vs. Presynch-10 cows (2.34 ± 0.09 vs. 2.15 ± 0.08) but not in primiparous cows (1.95 ± 0.10 vs. 1.98 ± 0.11). In summary, administering both PGF
and GnRH on the same day, 7 d before the start of Ovsynch, appears to be a simple and effective alternative to Presynch-10 Ovsynch. |
| format | Article |
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and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10. Lactating dairy cows (n = 432) 41 to 47 d in milk (DIM) were randomly assigned to 2 treatments within parities for first service. Control cows received Presynch-10/Ovsynch consisting of the following: PGF
-14 d-PGF
-10 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. Treated cows received PGF
and GnRH-7 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. All cows received a supplemental injection of PGF
24 h after the PGF
of Ovsynch to enhance complete luteolysis. All cows received timed AI between 75 and 81 DIM. Blood was collected to assess circulating concentrations of progesterone (P4), and the number and size of corpora lutea (CL) were recorded using ultrasonography on day of PGF
of Ovsynch. The administration of PGF
simultaneously with GnRH and 7 d before Ovsynch (PG+G) had similar P/AI at 28 (46 vs. 48%), 35 (43 vs. 43%), 49 (39 vs. 39%), and 77 d post-AI (38 vs. 39%) compared with Presynch-10. No differences were observed in P/AI in primiparous versus multiparous cows at 28 (52 vs. 45%), 35 (48 vs. 41%), 49 (45 vs. 37%), and 77 d post-AI (43 vs. 36%). No difference existed between treatments in percentage of cows with functional CL at PGF
of Ovsynch, total luteal area (mm
), or serum concentrations of P4 at time of PGF
of Ovsynch, regardless of parity. Number of CL had a tendency to be greater for multiparous PG+G vs. Presynch-10 cows (2.34 ± 0.09 vs. 2.15 ± 0.08) but not in primiparous cows (1.95 ± 0.10 vs. 1.98 ± 0.11). In summary, administering both PGF
and GnRH on the same day, 7 d before the start of Ovsynch, appears to be a simple and effective alternative to Presynch-10 Ovsynch.</description><identifier>EISSN: 1525-3198</identifier><identifier>PMID: 28434724</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cattle ; Corpus Luteum - anatomy & histology ; Corpus Luteum - diagnostic imaging ; Dinoprost - pharmacology ; Estrus ; Estrus Synchronization - methods ; Female ; Gonadotropin-Releasing Hormone - pharmacology ; Insemination, Artificial - methods ; Lactation ; Milk - metabolism ; Ovulation - physiology ; Parity ; Pregnancy ; Progesterone - blood ; Time Factors</subject><ispartof>Journal of dairy science, 2017-06, Vol.100 (6), p.5107</ispartof><rights>Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28434724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martins, J P N</creatorcontrib><creatorcontrib>Acevedo, M J T</creatorcontrib><creatorcontrib>Cunha, T O</creatorcontrib><creatorcontrib>Piterini, C</creatorcontrib><creatorcontrib>Pursley, J R</creatorcontrib><title>The effect of presynchronization with prostaglandin F 2α and gonadotropin-releasing hormone simultaneously, 7 d before Ovsynch, compared with Presynch-10/Ovsynch on luteal function and first-service pregnancies per artificial insemination</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH of Ovsynch. The hypothesis of this experiment was that simplification of a presynchronization program through the combination of PGF
and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10. Lactating dairy cows (n = 432) 41 to 47 d in milk (DIM) were randomly assigned to 2 treatments within parities for first service. Control cows received Presynch-10/Ovsynch consisting of the following: PGF
-14 d-PGF
-10 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. Treated cows received PGF
and GnRH-7 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. All cows received a supplemental injection of PGF
24 h after the PGF
of Ovsynch to enhance complete luteolysis. All cows received timed AI between 75 and 81 DIM. Blood was collected to assess circulating concentrations of progesterone (P4), and the number and size of corpora lutea (CL) were recorded using ultrasonography on day of PGF
of Ovsynch. The administration of PGF
simultaneously with GnRH and 7 d before Ovsynch (PG+G) had similar P/AI at 28 (46 vs. 48%), 35 (43 vs. 43%), 49 (39 vs. 39%), and 77 d post-AI (38 vs. 39%) compared with Presynch-10. No differences were observed in P/AI in primiparous versus multiparous cows at 28 (52 vs. 45%), 35 (48 vs. 41%), 49 (45 vs. 37%), and 77 d post-AI (43 vs. 36%). No difference existed between treatments in percentage of cows with functional CL at PGF
of Ovsynch, total luteal area (mm
), or serum concentrations of P4 at time of PGF
of Ovsynch, regardless of parity. Number of CL had a tendency to be greater for multiparous PG+G vs. Presynch-10 cows (2.34 ± 0.09 vs. 2.15 ± 0.08) but not in primiparous cows (1.95 ± 0.10 vs. 1.98 ± 0.11). In summary, administering both PGF
and GnRH on the same day, 7 d before the start of Ovsynch, appears to be a simple and effective alternative to Presynch-10 Ovsynch.</description><subject>Animals</subject><subject>Cattle</subject><subject>Corpus Luteum - anatomy & histology</subject><subject>Corpus Luteum - diagnostic imaging</subject><subject>Dinoprost - pharmacology</subject><subject>Estrus</subject><subject>Estrus Synchronization - methods</subject><subject>Female</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Insemination, Artificial - methods</subject><subject>Lactation</subject><subject>Milk - metabolism</subject><subject>Ovulation - physiology</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Time Factors</subject><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtOw0AMhiMkRMvjCsgHaESealkjKnaw6L6aTjyJ0cQTeSZF4VZchKtwBdKQrlnZsn7r--yLaJmWWRnn6eNmEV17_54kWZol5VW0yDZFXqyzYhn97BoENAZ1AGegE_QD60Yc06cK5Bg-KDTj3Pmgaqu4IoYtZN9fMPZQO1aVC-I64ljQovLENTROWscIntreBsXoem-HFayhggMaJwivxwm0Au3aTglWf6C3WSBOk4c5AqOE7QMqC6ZnPUmd2IbEh9ijHEnjybxmxZrQQ4cCSgIZ0jRuEXtsiadzbqNLo6zHu7neRPfb593TS9z1hxarfSfUKhn25w_l_wZ-Ab8xeYM</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Martins, J P N</creator><creator>Acevedo, M J T</creator><creator>Cunha, T O</creator><creator>Piterini, C</creator><creator>Pursley, J R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201706</creationdate><title>The effect of presynchronization with prostaglandin F 2α and gonadotropin-releasing hormone simultaneously, 7 d before Ovsynch, compared with Presynch-10/Ovsynch on luteal function and first-service pregnancies per artificial insemination</title><author>Martins, J P N ; Acevedo, M J T ; Cunha, T O ; Piterini, C ; Pursley, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_284347243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Corpus Luteum - anatomy & histology</topic><topic>Corpus Luteum - diagnostic imaging</topic><topic>Dinoprost - pharmacology</topic><topic>Estrus</topic><topic>Estrus Synchronization - methods</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Insemination, Artificial - methods</topic><topic>Lactation</topic><topic>Milk - metabolism</topic><topic>Ovulation - physiology</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, J P N</creatorcontrib><creatorcontrib>Acevedo, M J T</creatorcontrib><creatorcontrib>Cunha, T O</creatorcontrib><creatorcontrib>Piterini, C</creatorcontrib><creatorcontrib>Pursley, J R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, J P N</au><au>Acevedo, M J T</au><au>Cunha, T O</au><au>Piterini, C</au><au>Pursley, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of presynchronization with prostaglandin F 2α and gonadotropin-releasing hormone simultaneously, 7 d before Ovsynch, compared with Presynch-10/Ovsynch on luteal function and first-service pregnancies per artificial insemination</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2017-06</date><risdate>2017</risdate><volume>100</volume><issue>6</issue><spage>5107</spage><pages>5107-</pages><eissn>1525-3198</eissn><abstract>Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH of Ovsynch. The hypothesis of this experiment was that simplification of a presynchronization program through the combination of PGF
and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10. Lactating dairy cows (n = 432) 41 to 47 d in milk (DIM) were randomly assigned to 2 treatments within parities for first service. Control cows received Presynch-10/Ovsynch consisting of the following: PGF
-14 d-PGF
-10 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. Treated cows received PGF
and GnRH-7 d-GnRH-7 d-PGF
-56 h-GnRH-16 h-AI. All cows received a supplemental injection of PGF
24 h after the PGF
of Ovsynch to enhance complete luteolysis. All cows received timed AI between 75 and 81 DIM. Blood was collected to assess circulating concentrations of progesterone (P4), and the number and size of corpora lutea (CL) were recorded using ultrasonography on day of PGF
of Ovsynch. The administration of PGF
simultaneously with GnRH and 7 d before Ovsynch (PG+G) had similar P/AI at 28 (46 vs. 48%), 35 (43 vs. 43%), 49 (39 vs. 39%), and 77 d post-AI (38 vs. 39%) compared with Presynch-10. No differences were observed in P/AI in primiparous versus multiparous cows at 28 (52 vs. 45%), 35 (48 vs. 41%), 49 (45 vs. 37%), and 77 d post-AI (43 vs. 36%). No difference existed between treatments in percentage of cows with functional CL at PGF
of Ovsynch, total luteal area (mm
), or serum concentrations of P4 at time of PGF
of Ovsynch, regardless of parity. Number of CL had a tendency to be greater for multiparous PG+G vs. Presynch-10 cows (2.34 ± 0.09 vs. 2.15 ± 0.08) but not in primiparous cows (1.95 ± 0.10 vs. 1.98 ± 0.11). In summary, administering both PGF
and GnRH on the same day, 7 d before the start of Ovsynch, appears to be a simple and effective alternative to Presynch-10 Ovsynch.</abstract><cop>United States</cop><pmid>28434724</pmid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1525-3198 |
| ispartof | Journal of dairy science, 2017-06, Vol.100 (6), p.5107 |
| issn | 1525-3198 |
| language | eng |
| recordid | cdi_pubmed_primary_28434724 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cattle Corpus Luteum - anatomy & histology Corpus Luteum - diagnostic imaging Dinoprost - pharmacology Estrus Estrus Synchronization - methods Female Gonadotropin-Releasing Hormone - pharmacology Insemination, Artificial - methods Lactation Milk - metabolism Ovulation - physiology Parity Pregnancy Progesterone - blood Time Factors |
| title | The effect of presynchronization with prostaglandin F 2α and gonadotropin-releasing hormone simultaneously, 7 d before Ovsynch, compared with Presynch-10/Ovsynch on luteal function and first-service pregnancies per artificial insemination |
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