Possible Involvement of Hydrosulfide in B 12 -Dependent Methyl Group Transfer
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B -dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H₂S)...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2017-04, Vol.22 (4) |
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| creator | Toohey, John I |
| description | Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B
-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H₂S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B
-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H₂S in nerve tissue involving the "hypomethylation theory" that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B
or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer's disease. |
| doi_str_mv | 10.3390/molecules22040582 |
| format | Article |
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-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H₂S in nerve tissue involving the "hypomethylation theory" that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B
or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer's disease.</description><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules22040582</identifier><identifier>PMID: 28379205</identifier><language>eng</language><publisher>Switzerland</publisher><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase ; Methylation ; Oxidation-Reduction ; Sulfites - chemistry ; Sulfur - chemistry ; Vitamin B 12 - chemistry</subject><ispartof>Molecules (Basel, Switzerland), 2017-04, Vol.22 (4)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28379205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toohey, John I</creatorcontrib><title>Possible Involvement of Hydrosulfide in B 12 -Dependent Methyl Group Transfer</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B
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-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H₂S in nerve tissue involving the "hypomethylation theory" that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B
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-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H₂S in nerve tissue involving the "hypomethylation theory" that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B
or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer's disease.</abstract><cop>Switzerland</cop><pmid>28379205</pmid><doi>10.3390/molecules22040582</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecules (Basel, Switzerland), 2017-04, Vol.22 (4) |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Methylation Oxidation-Reduction Sulfites - chemistry Sulfur - chemistry Vitamin B 12 - chemistry |
| title | Possible Involvement of Hydrosulfide in B 12 -Dependent Methyl Group Transfer |
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